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A6060

Sigma-Aldrich

Calpain Inhibitor II

powder

Sinonimo/i:

N-Acetyl-L-leucyl-L-leucyl-L-methioninal

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5 MG
128,00 €
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504,00 €

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5 MG
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504,00 €

About This Item

Formula empirica (notazione di Hill):
C19H35N3O4S
Numero CAS:
110115-07-6
Peso molecolare:
401.56
Beilstein:
7693643
Numero MDL:
MFCD00065506
Codice UNSPSC:
12352200
ID PubChem:
24891051
NACRES:
NA.77

128,00 €

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Saggio

≥95% (HPLC)

Stato

powder

Colore

white

Solubilità

ethanol: 20 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

[H]C(=O)[C@H](CCSC)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(C)=O

InChI

1S/C19H35N3O4S/c1-12(2)9-16(20-14(5)24)19(26)22-17(10-13(3)4)18(25)21-15(11-23)7-8-27-6/h11-13,15-17H,7-10H2,1-6H3,(H,20,24)(H,21,25)(H,22,26)/t15-,16-,17-/m0/s1
RJWLAIMXRBDUMH-ULQDDVLXSA-N

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Applicazioni

Calpain Inhibitor II has been used in western blotting.[1] It has also been used to study the mechanism of Spy1A (a cyclin-like protein) degradation during cell cycle.[2]
Calpain inhibitor II is a cell-permeable peptide that restricts the activity of calpain, cathepsin L and cathepsin B. Calpain inhibitor II also prevents the methylmercury-induced cell death of cultured rat cerebellar neurons.

Azioni biochim/fisiol

Calpain is a cysteine protease expressed in the nervous system. Calpain exhibits a calcium-dependent enzyme activity. In mice models, inhibition of calpain prevents leukocyte infiltration induced by angiotensin II and also attenuates prevascular inflammation.[3]

Altre note

Formerly CAS# 136632-32-1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number
0000219876
045M4710V
074M4733V
063M4735V

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Calpain Inhibitor VI The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

208745

Calpain Inhibitor VI

PD 150606 ≥97% (HPLC)

Sigma-Aldrich

D5946

PD 150606

Calpastatin Peptide Ac 184-210 ≥95% (HPLC)

Sigma-Aldrich

SCP0063

Calpastatin Peptide Ac 184-210

Cathepsin Inhibitor I The Cathepsin Inhibitor I controls the biological activity of Cathepsin. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Sigma-Aldrich

219415

Cathepsin Inhibitor I

Calpeptin A cell-permeable calpain inhibitor (ID₅₀ = 52 nM for calpain-1; ID₅₀ = 34 nM for calpain-2; ID₅₀ = 138 nM for papain).

Sigma-Aldrich

03-34-0051

Calpeptin

Antipain dihydrochloride from microbial source protease inhibitor

Sigma-Aldrich

A6191

Antipain dihydrochloride from microbial source

CA-074 ≥98% (HPLC)

Sigma-Aldrich

C5732

CA-074

Motoharu Sakaue et al.
Toxicology, 213(1-2), 97-106 (2005-06-29)
Methylmercury, an environmental neurotoxicant, induces the apoptotic death of cerebellar granule cells in vitro at a low concentration. To further understand the mechanism of cell death, we used a rat cerebellar granule cell culture system to investigate whether the calpain/cyclin-dependent
Zachary A Gurard-Levin et al.
Antiviral research, 182, 104924-104924 (2020-09-09)
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the COVID-19 pandemic that began in 2019. The coronavirus 3-chymotrypsin-like cysteine protease (3CLpro) controls replication and is therefore considered a major target for antiviral discovery. This study describes the
Aneurysm: New Insights for the Healthcare Professional, 56-57 (2013)
J Sebastián Yakisich et al.
Investigational new drugs, 28(3), 242-250 (2009-03-17)
By using mini-units of tissue and protease inhibitors in short term incubation (0-180 min), we studied the role of proteolysis for ongoing DNA replication in the developing rat cerebral cortex. The protease inhibitors TLCK, TPCK, PMSF, MG-132 and PSI markedly
M W Luong et al.
Toxicology and industrial health, 25(3), 169-176 (2009-06-02)
The objective of this study was to examine the potential of arsenate to induce cardiomyocyte cell death and to explore the cellular mechanisms of arsenate toxicity. Isolated cardiomyocytes in culture from embryonic chick hearts were treated with a pentavalent arsenic
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