T176

4-idrossitamoxifene

analytical standard, (E) and (Z) isomers (50:50)

• Sinonimo/i: 4-(1-[4-(dimetilaminoetossi)fenil]-2-fenil-1-butenil)fenolo, 4-OHT, cis/trans4-idrossitamoxifene
• Formula empirica (notazione di Hill): C₂₆H₂₉NO₂
• Numero CAS: 68392-35-8
• Peso molecolare: 387.51
• Codice UNSPSC: 41116107
• ID PubChem: 24899989
• NACRES: NA.24

Proprietà

• Grado: analytical standard
• Livello qualitativo: 200
• Forma fisica: powder
• tecniche: HPLC: suitable; gas chromatography (GC): suitable
• Solubilità: ethanol: 20 mg/mL
• Spettro attività antibiotica: neoplastics
• applicazioni: forensics and toxicology; pharmaceutical (small molecule)
• Formato: neat
• Modalità d’azione: enzyme | inhibits
• Stringa SMILE: CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6
• InChI: 1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-; ZJLDABGSDWXVGE-BDSXMVAQSA-N
• Informazioni sul gene: human ... ESR1(2099) , ESR2(2100) , ESRRG(2104) , IL6(3569) ; rat ... Ar(24208) , Esr1(24890) , Esr2(25149)

Descrizione

Descrizione generale

4-Hydroxytamoxifen is an antiestrogenic agent and one of the active metabolites of tamoxifen, formed upon its hydroxylation cytochrome P4502D6 (CYP2D6). Tamoxifen is used significantly in breast cancer as hormonal therapy.

Applicazioni

The 4-Hydroxytamoxifen analytical standard can be used as follows:

• Determination of tamoxifen and its three metabolites from dried blood spot (DBS) discs by ultra-high performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS)
• Simultaneous estimation of tamoxifen, 4-hydroxytamoxifen, and endoxifen from DBS samples by UHPLC-MS/MS
• Development and validation of a non-aqueous capillary electrophoretic (NACE) method coupled with capacitively coupled contactless conductivity detection (C⁴D) to analyze tamoxifen and its three main metabolites after their liquid-liquid extraction (LLE) from human plasma samples obtained from breast cancer patients
• Multi-residue analysis of human plasma samples to quantify tamoxifen and its degradation products using the non-aqueous capillary electrophoretic (NACE) method combined with UV-detection
• Combined detection of tamoxifen and centchroman, along with their degradation products in human plasma samples by LC-ESI-MS/MS

Azioni biochim/fisiol

Metabolita del farmaco chemioterapico tamoxifene, mostra un′attività agonista/antagonista nei confronti degli estrogeni più potente rispetto al farmaco progenitore. È attivo anche come inibitore intramembranoso della perossidazione dei lipidi.

Altre note

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302 + H312 + H332,H315,H319,H361fd
• Consigli di prudenza: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges