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Documenti

94873

Supelco

4-idrossitamoxifene

(E) and (Z) isomers (50:50), analytical standard

Sinonimo/i:

4-(1-[4-(dimetilaminoetossi)fenil]-2-fenil-1-butenil)fenolo, 4-OHT, cis/trans4-idrossitamoxifene

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About This Item

Formula empirica (notazione di Hill):
C26H29NO2
Numero CAS:
Peso molecolare:
387.51
Codice UNSPSC:
41116107
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥97.5% (HPLC)

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Impurezze

≤5.0% water

applicazioni

forensics and toxicology
pharmaceutical (small molecule)

Formato

neat

Stringa SMILE

CC\C(c1ccccc1)=C(/c2ccc(O)cc2)c3ccc(OCCN(C)C)cc3.CC\C(c4ccccc4)=C(\c5ccc(O)cc5)c6ccc(OCCN(C)C)cc6

InChI

1S/2C26H29NO2/c2*1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h2*5-17,28H,4,18-19H2,1-3H3/b26-25+;26-25-
ZJLDABGSDWXVGE-BDSXMVAQSA-N

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Descrizione generale

4-Hydroxytamoxifen is a first generation, selective estrogen receptor modulator (SERM) that functions as an antagonist in breast cancer cells but can display estrogen-like activities in the uterus and bone.

Applicazioni

4-Hydroxytamoxifen may be used as a reference standard in the determination of 4-hydroxythmoxifen in plasma samples using high-performance liquid chromatography with fluorescence detection (HPLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Azioni biochim/fisiol

Metabolita del farmaco chemioterapico tamoxifene, mostra un′attività agonista/antagonista nei confronti degli estrogeni più potente rispetto al farmaco progenitore. È attivo anche come inibitore intramembranoso della perossidazione dei lipidi.

Pittogrammi

Health hazardExclamation mark

Avvertenze

Warning

Classi di pericolo

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Certificati d'analisi (COA)

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