65943

N-Methyl-bis(trifluoroacetamide)

for GC derivatization, LiChropur^™, ≥99.0% (GC)

• Sinonimo/i: MBTFA
• Formula condensata: CF₃CON(CH₃)COCF₃
• Numero CAS: 685-27-8
• Peso molecolare: 223.07
• Beilstein: 1878402
• Numero CE: 211-680-5
• Numero MDL: MFCD00000412
• Codice UNSPSC: 12000000
• ID PubChem: 329760134
• NACRES: NA.22

Proprietà

• Grado: for GC derivatization
• Livello qualitativo: 100
• Saggio: ≥99.0% (GC)
• Qualità: LiChropur^™
• Impiego in reazioni chimiche: reagent type: derivatization reagent; reaction type: Acylations; reagent type: derivatization reagent; reaction type: Silylations
• tecniche: gas chromatography (GC): suitable
• Indice di rifrazione: n20/D 1.346 (lit.); n20/D 1.346
• P. eboll.: 121-122 °C (lit.)
• Densità: 1.547 g/mL at 25 °C
• Stringa SMILE: CN(C(=O)C(F)(F)F)C(=O)C(F)(F)F
• InChI: 1S/C5H3F6NO2/c1-12(2(13)4(6,7)8)3(14)5(9,10)11/h1H3; AWGBWLXGUPTXHF-UHFFFAOYSA-N

Descrizione

Descrizione generale

N-Methyl-bis(trifluoroacetamide) is a common reagent used in the alkylation process, which targets highly polar, multi-functional compounds such as carbohydrates and amino acids.

Applicazioni

N-Methyl-bis(trifluoroacetamide) may be used as an on-column derivatization agent for the determination of amphetamine-type stimulants in biological samples, and ketamine, norketamine, dehydronorketamine in urine samples using gas chromatography coupled to mass spectrometry technique.
It is a derivatization agent in GC-MS technique used as an alternative to trifluoroacetyl anhydride (TFAA) for trifluoroacylating primary and secondary amines, and the hydroxyl group under mild non-acidic conditions.
Reagent for introducing trifluoroacetyl group. Suitable for the derivatization of alcohols, amines, amino acids, carbohydrates(mono-,di-,tri- and tetrasaccharides, carboxylic acids, hydroxyamines, 3-hydroxy-1-nitrosopyrrolidine, indolalkylamine, phenolalkylamines, pyridoxal (and other B₆ vitamers), and thiols.

Reagent for introducing trifluoroacetyl group.

Altre note

Reagent for trifluoroacetyl, N-trimethylsilyl-N-tifluoroacetyl and trimethylsilyl.

Reagent for trifluoroacetylations under mild conditions

Note legali

LiChropur is a trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS02,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H226,H314
• Consigli di prudenza: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Classi di pericolo: Flam. Liq. 3 - Skin Corr. 1B
• Codice della classe di stoccaggio: 3 - Flammable liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): 113.0 °F - closed cup
• Punto d’infiammabilità (°C): 45 °C - closed cup
• Dispositivi di protezione individuale: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter