860492P

Sphingosine-1-Phosphate (d18:1)

Avanti Research^™ - A Croda Brand

• Sinonimo/i: D-erythro-sphingosine-1-phosphate
• Formula empirica (notazione di Hill): C₁₈H₃₈NO₅P
• Numero CAS: 26993-30-6
• Peso molecolare: 379.47
• Numero MDL: MFCD00270077
• Codice UNSPSC: 12352211
• NACRES: NA.25

Proprietà

• Stato: powder
• Confezionamento: pkg of 1 × 1 mg (860492P-1mg); pkg of 1 × 25 mg (860492P-25mg); pkg of 1 × 5 mg (860492P-5mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Tipo di lipide: sphingolipids
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@](/C=C/CCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O
• InChI: 1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1; DUYSYHSSBDVJSM-KRWOKUGFSA-N

Descrizione

Descrizione generale

Sphingosine-1-phosphate (S1P), a sphingolipid, is an important cellular metabolite and signaling lipid in animal cells. It has also been found in yeasts and plants.[1] Sphingosine kinases (SPKs) catalyzes the synthesis of S1P from spingosine[2] and regulates S1P levels.[3] It is the end product of ceramide catabolism and is metabolized to phosphoethanolamine and hexadecenal by S1P lyase. S1P is produced in endothelial cells.[4]

Applicazioni

Sphingosine-1-Phosphate (d18:1) has been used:

• as an internal standard in high performance liquid chromatography (HPLC) for the quantification of plasma lipid sphingosine-1-phosphate(S1P)[5]
• to evaluate its chemotactic response of auto reactive immature B cells[6]
• to test its effect on autophagy and preconditioning in oxygen and glucose deprived neurons[3]

Azioni biochim/fisiol

Sphingosine 1-phosphate (S1P) is a signaling molecule and an intracellular messenger, crucial for the physiological processes. It is implicated in the pathogenesis of osteoporosis, cancer, atherosclerosis and diabetes.[2] S1P regulates skin dendritic cells and keratinocytes, and its anti-inflammatory functionality is useful in treating atopic dermatitis.[4] S1P coordinates T lymphocytes circulation in lymph, plasma and tissue by interacting with G-protein coupled receptors (GPCRS).[6] S1P is a high affinity ligand for sphingosine-1-phosphate receptor (S1P1−5).[7]

Confezionamento

5 mL Amber Glass Screw Cap Vial (860492P-1mg)

5 mL Amber Glass Screw Cap Vial (860492P-25mg)

5 mL Amber Glass Screw Cap Vial (860492P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable