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860498P

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Sphinganine (d18:0)

Avanti Research™ - A Croda Brand

Sinonimo/i:

D-erythro-sphinganine

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About This Item

Formula empirica (notazione di Hill):
C18H39NO2
Numero CAS:
764-22-7
Peso molecolare:
301.51
Codice UNSPSC:
12352211
NACRES:
NA.25

Forma fisica

powder

Confezionamento

pkg of 1 × 10 mg (860498P-10mg)
pkg of 1 × 100 mg (860498P-100mg)
pkg of 1 × 25 mg (860498P-25mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand

Tipo di lipide

sphingolipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

OC[C@@](N)([H])[C@]([H])(O)CCCCCCCCCCCCCCC

InChI

1S/C18H39NO2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(21)17(19)16-20/h17-18,20-21H,2-16,19H2,1H3/t17-,18+/m0/s1
OTKJDMGTUTTYMP-ZWKOTPCHSA-N

Categorie correlate

Descrizione generale

Sphinganine (d18:0) is a substrate for the enzyme ceramide desaturase. It is synthesized indirectly due to the interconversion of supplemented glycine to serine. Sphinganine (d18:0) is catabolized to ceramide.

Applicazioni

Sphinganine (d18:0) has been used:
  • as a standard in liquid chromatography tandem mass spectrophotometry for the quantification of epidermal ceramides
  • as a medium supplement to test its effect on growth of yeast cells
  • in the preparation of bovine serum albumin lipid complex to investigate its effect on non-lysosomal - glucosylceramidase β2 (GBA2) inhibition

Azioni biochim/fisiol

Sphinganine (d18:0) levels are not altered in hereditary sensory neuropathy type 1 cells. Accumulation of d18:0 is observed in tumor hypoxia. It is useful as a biomarker for studying microbial diversity.

Confezionamento

5 mL Amber Glass Screw Cap Vial (860498P-100mg)
5 mL Amber Glass Screw Cap Vial (860498P-10mg)
5 mL Amber Glass Screw Cap Vial (860498P-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sphingosine-1-Phosphate (d17:1) Avanti Research™ - A Croda Brand

Avanti

860641P

Sphingosine-1-Phosphate (d17:1)

Tetraacetylphytosphingosine ≥98% (HPLC)

Sigma-Aldrich

SMB00703

Tetraacetylphytosphingosine

C16 Ceramide (d18:1/16:0) Avanti Research™ - A Croda Brand

Avanti

860516P

C16 Ceramide (d18:1/16:0)

Sunyoung Hwang et al.
Cell reports, 29(8), 2473-2488 (2019-11-21)
An abnormal number of chromosomes, or aneuploidy, accounts for most spontaneous abortions, causes developmental defects, and is associated with aging and cancer. The molecular mechanisms by which aneuploidy disrupts cellular function remain largely unknown. Here, we show that aneuploidy disrupts
Identification of a feedback loop involving beta-glucosidase 2 and its product sphingosine sheds light on the molecular mechanisms in Gaucher disease
Schonauer S, et al.
Test, 292(15), 6177-6189 (2017)
Altered sphingolipid metabolism induced by tumor hypoxia-new vistas in glycolipid tumor markers
Yin J, et al.
Febs Letters, 584(9), 1872-1878 (2010)
Transcription factor Ctip2 controls epidermal lipid metabolism and regulates expression of genes involved in sphingolipid biosynthesis during skin development
Wang Z, et al.
The Journal of Investigative Dermatology, 133(3), 668-676 (2013)
Mirthe Muilwijk et al.
BMJ open diabetes research & care, 8(1) (2020-05-08)
People of South Asian origin are at high risk of type 2 diabetes (T2D), but the underpinning mechanisms are not fully understood. We determined ethnic differences in acylcarnitine, amino acid and sphingolipid concentrations and determined the associations with T2D. Associations
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