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T9950
Tau-352 human
recombinant, expressed in E. coli, ≥90% (SDS-PAGE), lyophilized powder
Szinonimák:
Human Tau Protein
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Javasolt termékek
biológiai forrás
human
Minőségi szint
rekombináns
expressed in E. coli
Teszt
≥90% (SDS-PAGE)
form
lyophilized powder
molekulatömeg
36.8 kDa
UniProt elérési szám
alkalmazás(ok)
cell analysis
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
Géninformáció
human ... MAPT(4137)
Alkalmazás
Tau-352 human is a Tau isoform, variant 0N3R which means it consists of 3 microtubule binding repeats (R) and no amino terminal inserts (N). The product can be utilized for systemic identification of Phosphorylation sites in microtubule-associated protein tau by using checkpoint kinases Chk1 and Chk2 in vitro.
Biokémiai/fiziológiai hatások
Tau-383 human belongs to neuronal microtubule-associated protein family that stimulates the microtubule assembly and stability as well as facilitates hyperphosphorylation-induced self-assembly into filaments. Tau protein along with src can upregulate tyrosine kinase activity. Inhibition of Src kinase influences the action of tau on actin rearrangements which in turn impacts the growth-factor-induced actin remodeling.
Isoform of Tau, variant 0N3R, having 3 microtubule binding repeats (R) and no amino terminal inserts (N).
Feloldás
Lyophilized from MES, pH 6.8, containing NaCl and EGTA. When reconstituted in water to a protein concentration of 1 mg/mL, the resulting buffer will have ~50 mM MES, pH 6.8, 100 mM NaCl, and 0.5 mM EGTA.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Jhoana Mendoza et al.
Journal of proteome research, 12(6), 2654-2665 (2013-04-05)
Hyperphosphorylation of microtubule-associated protein tau is thought to contribute to Alzheimer's disease (AD) pathogenesis. We previously showed that DNA damage-activated cell cycle checkpoint kinases Chk1 and Chk2 phosphorylate tau at an AD-related site and enhance tau toxicity, suggesting potential roles
Jesus Avila et al.
Physiological reviews, 84(2), 361-384 (2004-03-27)
The morphology of a neuron is determined by its cytoskeletal scaffolding. Thus proteins that associate with the principal cytoskeletal components such as the microtubules have a strong influence on both the morphology and physiology of neurons. Tau is a microtubule-associated
Vandana M Sharma et al.
Journal of cell science, 120(Pt 5), 748-757 (2007-02-08)
The microtubule-associated protein tau interacts with the SH3 domain of non-receptor Src family protein tyrosine kinases. A potential consequence of the SH3 interaction is the upregulation of tyrosine kinase activity. Here we investigated the activation of Src or Fyn by
A Himmler et al.
Molecular and cellular biology, 9(4), 1381-1388 (1989-04-01)
Tau proteins consist of a family of proteins, heterogeneous in size, which associate with microtubules in vivo and are induced during neurite outgrowth. In humans, tau is one of the major components of the pathognomonic neurofibrillary tangles in Alzheimer's disease
M Goedert et al.
Neuron, 3(4), 519-526 (1989-10-01)
We have determined the sequences of isoforms of human tau protein, which differ from previously reported forms by insertions of 29 or 58 amino acids in the amino-terminal region. Complementary DNA cloning shows that the insertions occur in combination with
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