T9030

Monoclonal Anti-Titin antibody produced in mouse

clone T11, ascites fluid

• Szinonimák: Anti-CMD1G, Anti-CMH9, Anti-CMPD4, Anti-EOMFC, Anti-HMERF, Anti-LGMD2J, Anti-LGMDR10, Anti-MYLK5, Anti-SALMY, Anti-TMD
• MDL-szám: MFCD00164750
• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: EM; IF; IHC (f); WB
• klón: T11, monoclonal
• faj reaktivitás: vertebrates, chicken
• citations: 22
• technika/technikák: electron microscopy: suitable; immunohistochemistry (frozen sections): suitable; indirect immunofluorescence: 1:1,000 using frozen tissue sections of animal skeletal muscle; western blot: suitable

Tulajdonságok

• biológiai forrás: mouse
• Minőségi szint: 200
• konjugátum: unconjugated
• antitest forma: ascites fluid
• antitest terméktípus: primary antibodies
• klón: T11, monoclonal
• tartalmaz: 15 mM sodium azide
• faj reaktivitás: vertebrates, chicken
• technika/technikák: electron microscopy: suitable; immunohistochemistry (frozen sections): suitable; indirect immunofluorescence: 1:1,000 using frozen tissue sections of animal skeletal muscle; western blot: suitable
• izotípus: IgG2b
• kiszállítva: dry ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: chicken ... TTN(424126)

Leírás

Általános leírás

Monoclonal Anti-Titin (mouse IgG2b isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. It is a flexible, filamentous constituent of striated muscle that is thought to give rise to an elastic filament component underlying the myofibrillar organization.

Titin (TTN), also known as connectin, is encoded by the gene mapped to human chromosome 2q31.2. TTN is a giant elastic protein expressed in striated and smooth muscles of vertebrates. The encoded protein contains up to 300 immunoglobulin-like and fibronectin type-3-like (FN3) domains.

Egyediség

The antibody localizes titin (connectin) in skeletal and heart muscle of a wide variety of species from cold-blooded vertebrates to human. The antibody does not cross-react with nebulin. Likewise, it does not react with smooth muscle, non-muscle tissues, or cultured cells.

Immunogén

titin/nebulin fraction from chicken breast muscle.

Alkalmazás

Monoclonal Anti-Titin antibody produced in mouse has been used in following studies.

• western blotting
• antibody staining
• immunofluorescence microscopy
• immunohistochemistry

Biokémiai/fiziológiai hatások

Monoclonal Anti-Titin can be used for study of the elastic filaments within sarcomeric structures. It is also useful as a differentiation marker in the separation of rhabdomyosarcomas from other muscle tumors.

Titin (TTN) helps in maintaining sarcomeric structural integrity by interacting with many other myofibrillar and cytoskeletal proteins. Additionally, it is also involved in developing the passive elastic force in muscle. Genetic variations in the gene has been associated with the development of dilated cardiomyopathy (DCM).

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: nwg
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable