SML1689

Eupatilin

from (Isolated from Artemisia sp.), ≥98% (HPLC), powder, lipophilic flavonoid

• Szinonimák: 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxy-4H-1-benzopyran-4-one, 5,7-Dihydroxy-3′,4′,6-trimethoxyflavone, NSC 122413
• Tapasztalati képlet (Hill-képlet): C₁₈H₁₆O₇
• CAS-szám: 22368-21-4
• Molekulatömeg: 344.32
• MDL-szám: MFCD13194819
• UNSPSC kód: 12352200
• PubChem Substance ID: 329826018
• NACRES: NA.77

Tulajdonságok

• Terméknév: Eupatilin, ≥98% (HPLC)
• biológiai forrás: (Isolated from Artemisia sp.)
• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• Forma: powder
• tárolási körülmény: desiccated; protect from light
• szín: white to beige
• oldhatóság: DMSO: 20 mg/mL, clear
• tárolási hőmérséklet: −20°C
• SMILES string: O=C1C=C(C2=CC=C(OC)C(OC)=C2)OC3=CC(O)=C(OC)C(O)=C31
• InChI: 1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3
• Nemzetközi kémiai azonosító kulcs: DRRWBCNQOKKKOL-UHFFFAOYSA-N

Leírás

Alkalmazás

Eupatilin has been used to investigate its inhibitory effects on intracranial hemorrhage (ICH)-induced inflammation and its anti-inflammatory mechanisms in mouse BV2 cells, in vitro. It has also been used as a standard for its quantitative estimation in Artemisia extracts by microcolumn high performance liquid chromatography with diode array (HPLC-DAD) assay.

Biokémiai/fiziológiai hatások

Eupatilin is a flavone with anti-oxidative, anti-inflammatory, and anti-cancer properties.

Eupatilin is an important constituent in the leaves of Artemisia argyi and also an active component of DA-9601. It exhibits anti-apoptotic effects. Eupatilin provides protection against tumor necrosis factor α (TNF-α)-mediated inflammation in human umbilical vein endothelial cells. It is used in the treatment of gastritis and peptic ulcers. Eupatilin safeguards gastric epithelial cells from oxidative damage and smooth muscle cells from indomethacin-induced cell damage. Eupatilin lowers bile acid-stimulated hepatocyte apoptosis.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable