SML0496

CORM-3

• Szinonimák: Carbon monoxide releasing molecule 3, Tricarbonylchloro(glycinato)ruthenium (II)
• Tapasztalati képlet (Hill-képlet): C₅H₄ClNO₅Ru
• CAS-szám: 475473-26-8
• Molekulatömeg: 294.61
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Forma: powder
• Minőségi szint: 100
• tárolási körülmény: desiccated
• szín: white to beige
• oldhatóság: H₂O: 20 mg/mL, clear
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• SMILES string: [Ru+2].[Cl-].NCC(=O)[O-].O=[C].O=[C].O=[C]
• InChI: 1S/C2H5NO2.3CO.ClH.Ru/c3-1-2(4)5;3*1-2;;/h1,3H2,(H,4,5);;;;1H;/q;;;;;+2/p-2

Leírás

Alkalmazás

CORM-3 (carbon monoxide (CO) releasing molecule-3) has been used to study its effect on NLRP3 (leucine-rich-repeat-containing receptor, pyrin-domain-containing 3) inflammasome activation via glycolysis in macrophages and also on hyperglycemia-induced IL-1β (interleukin-1 β) production. It has also been used to study its protective function against H₂O₂-induced apoptosis using primary rabbit lens epithelial cells.

Biokémiai/fiziológiai hatások

CO possesses anti apoptotic function and offers protection against oxidative damage, promoting endothelial healing. CORM-3 is known to have therapeutic effects in transplantation, myocardial infarction and rheumatoid arthritis.

CORM-3 is a water-soluble carbon monoxide (CO) releasing molecule that can be used to study the effects of CO on cellular systems. Carbon monoxide (CO), produced during the degradation of heme by the enzyme heme oxygenase, has recently been found to be an important gaseous signaling mediator in mammalian cells CORM-3 has been shown to have anti-inflammatory and cardioprotective activity.

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable