Összes fotó(1)
Fontos dokumentumok
SBR00024
Trimethoprim Ready Made Solution
25 mg/mL in DMSO
Szinonimák:
Trimethoprim Ready Made Solution
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C14H18N4O3
Molekulatömeg:
290.32
UNSPSC kód:
51285203
NACRES:
NA.76
Javasolt termékek
biológiai forrás
synthetic
Teszt
≥98% (HPLC)
form
liquid
koncentráció
25 mg/mL in DMSO
szín
colorless to faint yellow
antibiotikus hatásspektrum
Gram-negative bacteria
Gram-positive bacteria
mycobacteria
Hatásmechanizmus
DNA synthesis | interferes
enzyme | inhibits
tárolási hőmérséklet
−20°C
InChI
1S/C14H18N4O3/c1-19-10-5-8(6-11(20-2)12(10)21-3)4-9-7-17-14(16)18-13(9)15/h5-7H,4H2,1-3H3,(H4,15,16,17,18
Nemzetközi kémiai azonosító kulcs
IEDVJHCEMCRBQM-UHFFFAOYSA-N
Általános leírás
Trimethoprim, an aminopyrimidine antibiotic belonging to the methoxybenzenes group, exhibits activity against a broad spectrum of both gram-negative and gram-positive aerobic bacteria. As a synthetic derivative of pyrimidine, it plays a multifaceted role as an inhibitor, xenobiotic, and allergen, featuring antibacterial, diuretic, and antiprotozoal properties. Trimethoprim selectively targets dihydrofolate reductase (DHFR), diminishing the levels of tetrahydrofolate that supply one-carbon units crucial for biosynthesis processes, including nucleotides, proteins, and panthotenate, especially in prokaryotic microorganisms.
Additionally, it is frequently employed in combination with sulfamethoxazole (sc-208405) to effectively inhibit the growth of Staphylococcus aureus, functioning as a dihydrofolate reductase inhibitor. This versatile compound finds applications in metabolomics, cell biology, and biochemical research.
Additionally, it is frequently employed in combination with sulfamethoxazole (sc-208405) to effectively inhibit the growth of Staphylococcus aureus, functioning as a dihydrofolate reductase inhibitor. This versatile compound finds applications in metabolomics, cell biology, and biochemical research.
Alkalmazás
Trimethoprim is used at a final concentration of ~4μg/mL for antibacterial activty.
Biokémiai/fiziológiai hatások
Mode of Action: Trimethoprim is an inhibitor of bacterial dihydrofolate reductase (DHFR), interfering with the conversion of dihydrofolate (DHF) to tetrahydrofolate (THF). THF is an essential precursor in the thymidine synthesis pathway, interference with this pathway inhibits bacterial DNA synthesis. Trimethoprim′s affinity for bacterial DHFR is several thousand times greater than its affinity for human DHFR.
Activity Spectrum: Effective against Gram-negative bacteria, Gram-positive bacteria, and mycobacteria
Some of the pathogens that trimethoprim can be effective against include:
Activity Spectrum: Effective against Gram-negative bacteria, Gram-positive bacteria, and mycobacteria
Some of the pathogens that trimethoprim can be effective against include:
- Escherichia coli (E. coli)
- Staphylococcus aureus (including methicillin-resistant Staphylococcus aureus or MRSA)
- Streptococcus pneumoniae
- Haemophilus influenzae
- Enterococcus faecalis
- Klebsiella species
- Proteus species
Tulajdonságok és előnyök
- High-quality antibiotic suitable for multiple research applications
- Ideal for Cell Biology, Metabolomics, and Biochemical research.
Egyéb megjegyzések
For additional information on our range of Biochemicals, please complete this form.
Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 2
Lobbanási pont (F)
188.6 °F
Lobbanási pont (C)
87 °C
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az ügyfelek ezeket is megtekintették
The binding of trimethoprim to bacterial dihydrofolate reductase.
D J Baker et al.
FEBS letters, 126(1), 49-52 (1981-04-06)
Stephen Hawser et al.
Biochemical pharmacology, 71(7), 941-948 (2005-12-20)
Although only a few DHFR inhibitors have progressed as antibiotics to the market there is much renewed interest in the discovery and development of new generation DHFR inhibitors as antibacterial agents. This article describes the success in exploiting DHFR as
A Binelli et al.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 150(3), 329-336 (2009-06-02)
A battery of eight biomarkers was applied in the freshwater mussel Dreissena polymorpha to evaluate potential sub-lethal effects of the antimicrobial trimethoprim (TMP, 5-[3,4,5-trimethoxybenzyl]pyrimidine-2,4-diamine). Mussels were exposed for 96 h to increasing concentrations (1, 3, 10 nM) of TMP in
Mahamadou A Thera et al.
The Journal of infectious diseases, 192(10), 1823-1829 (2005-10-20)
Trimethoprim-sulfamethoxazole (TS) prophylaxis is recommended for persons living with human immunodeficiency virus infection and acquired immunodeficiency syndrome in Africa. TS and the antimalarial combination sulfadoxine-pyrimethamine (SP) share mechanisms of action and resistance patterns, and concerns about the impact of TS
R N Brogden et al.
Drugs, 23(6), 405-430 (1982-06-01)
Trimethoprim, which has been widely available for several years in combination with sulphamethoxazole as co-trimoxazole, is now available for use alone in the treatment of acute uncomplicated urinary tract infections. Trimethoprim, which is active against a wide range of Gram-positive
Cikkek
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