SAB5701610

Anti- RAG2 antibody produced in rabbit

• UNSPSC kód: 12352203
• NACRES: NA.41
• klón: polyclonal
• application: IHC; WB
• faj reaktivitás: mouse, human, rat
• technika/technikák: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: liquid
• faj reaktivitás: mouse, human, rat
• koncentráció: 1.58 mg/mL
• technika/technikák: immunohistochemistry: 1:50-1:200; western blot: 1:500-1:2000
• UniProt elérési szám: P55895
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... RAG2(5897)

Leírás

Általános leírás

This gene encodes a protein that is involved in the initiation of V(D)J recombination during B and T cell development. This protein forms a complex with the product of the adjacent recombination activating gene 1, and this complex can form double-strand breaks by cleaving DNA at conserved recombination signal sequences. The recombination activating gene 1 component is thought to contain most of the catalytic activity, while the N-terminal of the recombination activating gene 2 component is thought to form a six-bladed propeller in the active core that serves as a binding scaffold for the tight association of the complex with DNA. A C-terminal plant homeodomain finger-like motif in this protein is necessary for interactions with chromatin components, specifically with histone H3 that is trimethylated at lysine 4. Mutations in this gene cause Omenn syndrome, a form of severe combined immunodeficiency associated with autoimmune-like symptoms.

Immunogén

Recombinant fusion protein containing a sequence corresponding to amino acids 258-527 of human RAG2 (NP_001230715.1).

Fizikai forma

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable