SAB5500023

Anti-N-Cadherin, Rabbit monoclonal

recombinant, expressed in proprietary host, clone SP90, affinity isolated antibody

• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: FACS; IHC
• klón: SP90, monoclonal
• faj reaktivitás: human (tested)
• citations: 1
• technika/technikák: flow cytometry: 1:100; immunohistochemistry: 1:100

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• rekombináns: expressed in proprietary host
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: SP90, monoclonal
• faj reaktivitás: human (tested)
• faj reaktivitás (homológia által előrejelzett): mouse, bovine, rat
• technika/technikák: flow cytometry: 1:100; immunohistochemistry: 1:100
• izotípus: IgG
• UniProt elérési szám: P19022
• alkalmazás(ok): research pathology
• kiszállítva: wet ice
• tárolási hőmérséklet: 2-8°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... CDH2(1000)

Leírás

Általános leírás

N-cadherin is a 140kDa protein belonging to a family of transmembrane molecules that mediate calcium-dependent intercellular adhesion. Cadherins are involved in controlling morphogenetic movements during development and regulate cell surface adhesion through homotypic adhesion with the same cadherin species. The function of N-cadherin is dependent on its association with the actin-cytoskeleton and is mediated through interactions between the C-terminal region of N-cadherin and the cytoplasmic catenin proteins. The stability of this association is regulated by phosphorylation and dephosphorylation of β-catenin. This gene is a classical cadherin from the cadherin superfamily. The encoded protein is a calcium dependent cell-cell adhesion glycoprotein comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. The protein functions during gastrulation and is required for establishment of left-right asymmetry. At certain central nervous system synapses, presynaptic to postsynaptic adhesion is mediated at least in part by this gene product.

Immunogén

Synthetic peptide corresponding to C-terminus of human cadherin-N protein.

Tulajdonságok és előnyök

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Fizikai forma

0.1 ml rabbit monoclonal antibody purified by protein A/G in PBS/1% BSA buffer pH 7.6 with less than 0.1% sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable