SAB4300110

Anti-phospho-CDK2 (pThr¹⁶⁰) antibody produced in rabbit

affinity isolated antibody

• Szinonimák: Anti-cyclin-dependent kinase 2 antibody produced in rabbit, Anti-p33(CDK2) antibody produced in rabbit
• MDL-szám: MFCD00675227
• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: IHC (p); WB
• klón: polyclonal
• faj reaktivitás: rat, human, mouse
• citations: 2
• technika/technikák: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: ~34 kDa
• faj reaktivitás: rat, human, mouse
• koncentráció: 1 mg/mL
• technika/technikák: immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100; western blot: 1:500-1:1000
• izotípus: IgG
• immunogén szekvencia: (T-Y-TP-H-E)
• NCBI elérési szám: NP_001789.2
• UniProt elérési szám: P24941
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: phosphorylation (pThr160)
• Géninformáció: human ... CDK2(1017)

Leírás

Általános leírás

Cyclin-dependent kinase 2 (CDK2), a nucleus-cytoplasm trafficking protein, belongs to the cyclin-dependent kinase (CDK) family. The CDK2 gene is located on human chromosome 12q13.2.

Immunogén

Peptide sequence around phosphorylation site of threonine 160 (T-Y-T(p)-H-E), according to the protein CDK2.

Biokémiai/fiziológiai hatások

Cyclin-dependent kinase 2 (CDK2) protein participates in the recombination and differentiation of the cell. It plays a major role in metabolism, apoptosis, senescence, and meiosis. CDK2 is involved in the development of embryos and the remodeling of chromatin. It also plays a key role in DNA damage and DNA damage response (DDR). CDK2 controls the progression of the cell cycle. Changes in the activity of CDK2 might have an impact on human carcinogenesis. Absence of CDK2 results in DNA damage and DDR activation.

Tulajdonságok és előnyök

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Cél megnevezése

Involved in the control of the cell cycle. Interacts with cyclins A, B1, B3, D, or E. Activity of CDK2 is maximal during S phase and G2.

Fizikai forma

Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable