SAB3500977

Anti-ACE2 antibody produced in rabbit

affinity isolated antibody

• UNSPSC kód: 12352203
• NACRES: NA.41
• konjugátum: unconjugated
• application: ELISA; IF; IHC
• klón: polyclonal
• faj reaktivitás: human
• citations: 3
• technika/technikák: ELISA: suitable; immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: predicted mol wt 89 kDa
• faj reaktivitás: human
• koncentráció: 1 mg/mL
• technika/technikák: ELISA: suitable; immunoblotting: suitable; immunofluorescence: suitable; immunohistochemistry: suitable
• NCBI elérési szám: NP_068576
• UniProt elérési szám: Q9BYF1
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... ACE2(59272)

Leírás

Általános leírás

Angiotensin-converting enzyme-2 (ACE2), also referred as ACEH (human ACE homolog), is an integral membrane protein. It is encoded by the gene located at human chromosome Xp22.2. Ace 2 is found in variety of tissues, but the higher levels of protein is observed in vascular endothelium, lungs, heart, kidney, and testis. The protein contains a N-terminal single catalytic metallopeptidase unit, a C-terminal noncatalytic domain and a cytoplasmic tail.

Immunogén

Antibody was raised against a synthetic peptide corresponding to amino acids near the C-terminus of human ACE2.

Biokémiai/fiziológiai hatások

Angiotensin-converting enzyme-2 (ACE2) as a carboxypeptidase cleaves angiotensin (Ang) I to Ang 1-9. In addition, it also degrades Ang II to Ang 1–7 and plays a vital role in regulation of blood pressure. Ace 2 aids in maintaining the balance of local renin-angiotensin system (RAS). It also helps in absorbing the neutral amino acids from the intestine and the kidney. It is a cellular receptor for spike glycoprotein of severe acute respiratory syndrome-coronavirus (SARS-CoV) and the new coronavirus (SARS-CoV-2), which is known to cause coronavirus disease 2019 (COVID-19). Downregulated expression of Ace 2 has been observed in patients with cardiovascular diseases.

Tulajdonságok és előnyök

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Kapcsolódás

The action of this antibody can be blocked using blocking peptide SBP3500977.

Fizikai forma

Supplied at 1 mg/mL in PBS with 0.02% sodim azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable