Összes fotó(3)
Fontos dokumentumok
MAK040
Adipogenesis Kit
sufficient for 100 colorimetric or fluorometric tests
Szinonimák:
Triglyceride Assay Kit
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(3)
About This Item
UNSPSC kód:
12161503
NACRES:
NA.25
Javasolt termékek
használat
sufficient for 100 colorimetric or fluorometric tests
észlelési módszer
colorimetric
fluorometric
vonatkozó betegség(ek)
endocrinological disorders, diabetes; cardiovascular diseases; cancer
tárolási hőmérséklet
−20°C
Általános leírás
Adipogenesis is the differentiation of pre-adipocytes derived from pluripotent mesenchymal cells into mature adipocytes. Adipocytes, which are capable of storing large quantities of lipids as triglycerides, are the main cells for lipid storage in animals. Adipose tissue plays a critical role in the regulation of whole-body energy homeostasis and adipocyte dysfunction has been implicated in pathological states such as cancer, type II diabetes, cardiovascular disease, and atherosclerosis.
Omental adipocytes are known to promote the invasion and progression of cancer cells especially, ovarian cancer. Close proximity of tumor cells and adipocytes, causes a phenotypic change resulting in the formation of adipocyte-derived fibroblasts, which directly promotes tumor progression. Elevated level of adiponectin produced by adipocytes is observed in heart failure patients, cardiovascular disease, and atherosclerosis. Excess cytokines such as TNFα (tumor necrosis factor -α) in adipocytes results in chronic inflammatory state and inhibits the process of adipogenesis. Adipocytes are known to maintain glucose homeostasis. Adipocytes regulates the entry of fatty acids into circulation and skeletal muscle. This action of adipocytes is associated with the development of type 2 diabetes, which indicates insulin resistance as a result of high levels of fatty acids in the blood.
Omental adipocytes are known to promote the invasion and progression of cancer cells especially, ovarian cancer. Close proximity of tumor cells and adipocytes, causes a phenotypic change resulting in the formation of adipocyte-derived fibroblasts, which directly promotes tumor progression. Elevated level of adiponectin produced by adipocytes is observed in heart failure patients, cardiovascular disease, and atherosclerosis. Excess cytokines such as TNFα (tumor necrosis factor -α) in adipocytes results in chronic inflammatory state and inhibits the process of adipogenesis. Adipocytes are known to maintain glucose homeostasis. Adipocytes regulates the entry of fatty acids into circulation and skeletal muscle. This action of adipocytes is associated with the development of type 2 diabetes, which indicates insulin resistance as a result of high levels of fatty acids in the blood.
Alkalmazás
Adipogenesis Kit has been used to study the intramyocellular triglyceride accumulation in myotubes. It has been used to study the effect of NS5ABP37 on hepatocellular carcinoma by determining the total intracellular triglyceride.
Alkalmasság
Suitable for the quantification of triglyceride accumulation in cells and tissue
Elv
In this kit, total cellular and tissue concentrations of triglycerides are determined by a coupled enzyme assay, which results in a colorimetric (570 nm)/ fluorometric (λex = 535/λem = 587 nm) product, proportional to the triglycerides present. This kit is able to detect triglycerides in as few as 1 × 104 differentiated 3T3 L1 cells.
Figyelmeztetés
Danger
Figyelmeztető mondatok
Óvintézkedésre vonatkozó mondatok
Veszélyességi osztályok
Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1
Tárolási osztály kódja
10 - Combustible liquids
Lobbanási pont (F)
188.6 °F - closed cup
Lobbanási pont (C)
87 °C - closed cup
Válasszon a legfrissebb verziók közül:
Analitikai tanúsítványok (COA)
Lot/Batch Number
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A new role for the natriuretic peptides: metabolic regulators of the adipocyte.
Costello-Boerrigter L C and Burnett J C
Journal of the American College of Cardiology (2009)
Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth.
Nieman K M, et al.
Nature Medicine, 17(11), 1498-1498 (2011)
Defining the role of DAG, mitochondrial function and lipid deposition in palmitate-induced proinflammatory signalling and its counter-modulation by palmitoleate.
Macrae K, et al.
Journal of Lipid Research, M036996-M036996 (2013)
Chien-Liang Fang et al.
Frontiers in pharmacology, 9, 155-155 (2018-03-22)
The dermis of human skin contains large numbers of fibroblasts that are responsible for the production of the extracellular matrix (ECM) that supporting skin integrity, elasticity and wound healing. Previously, an in vivo study demonstrated that dermal fibroblasts siting in
Adipocyte-Derived Fibroblasts promote tumor progression and contribute to desmoplastic reaction in breast cancer.
Bochet L, et al.
Cancer Research, 530-530 (2013)
Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.
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