Összes fotó(2)
Fontos dokumentumok
L5037
Leptin from rat
≥97% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder
Szinonimák:
OB
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(2)
About This Item
Javasolt termékek
rekombináns
expressed in E. coli
Minőségi szint
sterilitás
non-sterile
Teszt
≥97% (SDS-PAGE)
form
lyophilized powder
hatékonyság
≤0.8 ng/mL ED50
molekulatömeg
16 kDa
szennyeződések
≤1.0 EU/μg endotoxin
UniProt elérési szám
kiszállítva
ambient
tárolási hőmérséklet
−20°C
Géninformáció
rat ... Lep(25608)
Alkalmazás
Leptin from rat has been used:
- to check the effect of intranasal nerve growth factor (NGF) on NGF activity in the spinal cord of Sprague-Dawley rats
- for validation of labelling for leptin-bearing cells of Sprague-Dawley rats
- to study the effect of leptin on STAT3 (signal transducer and activator of transcription 3) phosphorylation in neural population of Sprague-Dawley rats
- to study leptin response towards chemoreflex in nucleus of the solitary tract
- in rats, to check the effect of association between leptin and neuronal nitric oxide pathway on penicillin-induced epileptiform activity
Biokémiai/fiziológiai hatások
In rodents with uncontrolled diabetes mellitus, leptin is crucial for normalizing hyperglycemia. In the digestive tract, it also participates in the absorption of dietary molecules via controlling transporters activity.
Leptin is a hormone produced primarily in adipocytes, although leptin mRNA has also been identified in placenta and fetal tissues, gastric tissue and liver. Its primary site of action appears to be on neurons in the hypothalamus that are involved in regulating energy balance, appetite, and body weight. Leptin increases the production of nitric oxide in endothelial cells and stimulates angiogenesis in vitro and in vivo.
Human and mouse leptin share ~84% sequence identity.
Human and mouse leptin share ~84% sequence identity.
Fizikai forma
Lyophilized from a 0.2 μm filtered solution with 4.5 mM NaHCO3.
Analízis megjegyzés
The biological activity is measured by its ability to induce proliferation of leptin-dependent human OB-R transfected murine BAF3 cells.
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, type N95 (US)
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Gregory J Morton et al.
The Journal of clinical investigation, 125(12), 4587-4591 (2015-11-04)
Leptin administration restores euglycemia in rodents with severe insulin-deficient diabetes, and recent studies to explain this phenomenon have focused on the ability of leptin to normalize excessive hypothalamic-pituitary-adrenal (HPA) axis activity. Here, we employed a streptozotocin-induced rat model (STZ-DM) of
Iris A McDuffie et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 52(2), 263-273 (2004-01-20)
Leptin, the ob protein, regulates food intake and satiety and can be found in the anterior pituitary. Leptin antigens and mRNA were studied in the anterior pituitary (AP) cells of male and female rats to learn more about its regulation.
Luigi Aloe et al.
Neural regeneration research, 9(10), 1025-1030 (2014-09-11)
The purpose of this work was to investigate whether, by intranasal administration, the nerve growth factor bypasses the blood-brain barrier and turns over the spinal cord neurons and if such therapeutic approach could be of value in the treatment of
Ali Aslan et al.
Brain research, 1321, 117-124 (2010-02-02)
The aim of the present study was to investigate the role of NO as a mediator of leptin action at the penicillin-induced epileptiform activity in rat. Thirty minutes after penicillin injection, leptin, at a dose of 1 microg, significantly increased
John Ciriello et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 303(7), R727-R736 (2012-08-24)
Circulating levels of leptin are elevated in individuals suffering from chronic intermittent hypoxia (CIH). Systemic and central administration of leptin elicits increases in sympathetic nervous activity (SNA), arterial pressure (AP), and heart rate (HR), and it attenuates the baroreceptor reflex
Cikkek
Lipid Induced Insulin Resistance
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