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I9534

Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat

Name: Monoclonal Anti-Insulin-like Growth Factor-II antibody produced in rat
Brand: SIGMA

clone 122404, purified immunoglobulin, lyophilized powder

Szinonimák:

Anti-Igf-II, Anti-Igf2, Anti-Mpr, Anti-Peg2

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez

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About This Item

UNSPSC kód:

51111800

NACRES:

NA.41

biológiai forrás

rat

konjugátum

unconjugated

antitest forma

purified immunoglobulin

antitest terméktípus

primary antibodies

klón

122404, monoclonal

form

lyophilized powder

faj reaktivitás

mouse

technika/technikák

capture ELISA: 2-8 μg/mL
western blot: 1-2 μg/mL

izotípus

IgG2a

UniProt elérési szám

P09535

tárolási hőmérséklet

−20°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

mouse ... Igf2(16002)

Immunogen

purified, E. coli-derived recombinant mouse insulin-like growth factor-II.

Biokémiai/fiziológiai hatások

Insulin-like growth factors -I and -II are important regulators of signaling that mediates growth and metabolism in cells. Insulin-like growth factor -II (IGF-II) is widely expressed during embryonic stages and regulates the placental development. IGF-II acts via specific receptor, IGF-IIR, the binding does not result in signal transduction, but is a mechanism to restrict the bioavailability of IGF-II. The effects of IGF-II signaling are important in growth of blood vessels (angiogenesis) gene transcription, proliferation and transformation.

Fizikai forma

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline containing carbohydrates.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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kapcsolódó termék

Product No.

Leírás

Árazás

Tárolási osztály kódja

13 - Non Combustible Solids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Egyéni védőeszköz

Eyeshields, Gloves, type N95 (US)

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Small is beautiful: insulin-like growth factors and their role in growth, development, and cancer.

Robert G Maki

Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 28(33), 4985-4995 (2010-10-27)

Insulin-like growth factors were discovered more than 50 years ago as mediators of growth hormone that effect growth and differentiation of bone and skeletal muscle. Interest of the role of insulin-like growth factors in cancer reached a peak in the

IGF2: epigenetic regulation and role in development and disease.

Wendy Chao et al.

Cytokine & growth factor reviews, 19(2), 111-120 (2008-03-01)

Insulin-like growth factor II (IGF2) is perhaps the most intricately regulated of all growth factors characterized to date. Its gene is imprinted--only one allele is active, depending on parental origin--and this pattern of expression is maintained epigenetically in almost all

Insulin-like growth factor system and sporadic malignant melanoma.

Ettore Capoluongo

The American journal of pathology, 178(1), 26-31 (2011-01-13)

Insulin and insulin-like growth factors (IGFs) are important regulators of energy metabolism and growth. Several findings have outlined an important role played by this family of molecules in both tumor maintenance and development. Despite the established contribution of the IGF

Serum insulin-like growth factors and insulin-like growth factor-binding proteins: clinical implications.

C J Rosen

Clinical chemistry, 45(8 Pt 2), 1384-1390 (1999-08-03)

The last decade has been characterized by a major investigative thrust into the physiology of two unique but ubiquitous peptides, insulin-like growth factor (IGF)-I and IGF-II. The regulatory systems that control the tissue bioactivity of the IGFs have been delineated

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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