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Fontos dokumentumok
GW22461F
Anti-Interleukin-2 antibody produced in chicken
affinity isolated antibody, buffered aqueous solution
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
UNSPSC kód:
12352203
NACRES:
NA.41
Javasolt termékek
biológiai forrás
chicken
Minőségi szint
konjugátum
unconjugated
antitest forma
affinity isolated antibody
antitest terméktípus
primary antibodies
klón
polyclonal
form
buffered aqueous solution
faj reaktivitás
rat, mouse, human
gyártó/kereskedő neve
Genway 15-288-22461F
technika/technikák
indirect ELISA: suitable
western blot: suitable
NCBI elérési szám
UniProt elérési szám
kiszállítva
wet ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... IL2(3558)
Általános leírás
IL2 (interleukin 2) is a pro-inflammatory cytokine, which is predominantly synthesized by activated T-cells and dendritic cells (DCs). T-cells also act as effector of IL-2 as they contain the interleukin 2 receptor (IL2R). This gene is localized to human chromosome 4q27, and codes for a glycoprotein with a molecular weight of 14-17kDa.
Alkalmazás
Anti-Interleukin-2 antibody produced in chicken is suitable for the production of anti-IL2 surface-conjugated microtoroids. It is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
Biokémiai/fiziológiai hatások
Interleukin 2 (IL-2) is an interleukin and is a cytokine signaling molecule in the immune system. It plays an important role in signal transduction for biological functions of IL-2. Upregulation of IL-2 combined with activation of IL-2-dependent signaling pathways may contribute to the pathogenesis of Focal cortical dysplasia (FCD). Aerosol interleukin-2 (IL-2) increases the number of intravenously injected human natural killer (NK) cells in the lungs by stimulating local NK cell proliferation. The effect on NK cell proliferation is organ specific, which makes it ideal for the specific targeting of lung metastasis.
Fizikai forma
Solution in phosphate buffered saline containing 0.02% sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 1
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Wei Guo et al.
Journal of neuropathology and experimental neurology, 73(3), 206-222 (2014-02-04)
Focal cortical dysplasia (FCD) is a well-known cause of medically intractable epilepsy. To understand the potential role of the inflammatory cytokine interleukin 2 (IL-2) in the pathogenesis of FCD, we investigated the expression patterns of IL-2 and its receptors (IL-2Rs)
Marta Fichna et al.
Molecular biology reports, 40(12), 6957-6963 (2013-10-25)
Polymorphic variants at the interleukin-2 (IL2) locus affect the risk of several autoimmune disorders. Our aim was to evaluate the association of the four IL2 polymorphisms (rs6822844, rs6534349, rs2069762 and rs3136534) with type 1 diabetes (T1D) in the Polish population
Hunter A Martinez et al.
Nature communications, 15(1), 1564-1564 (2024-02-21)
Although FOXP3+ regulatory T cells (Treg) depend on IL-2 produced by other cells for their survival and function, the levels of IL-2 in inflamed tissue are low, making it unclear how Treg access this critical resource. Here, we show that
Marcel Joly et al.
Journal of theoretical biology, 335, 57-78 (2013-06-29)
In this paper, we sought to identify the CD4(+) T-cell dynamics in the course of HIV infection in response to continuous and intermittent intravenous courses of interleukin-2 (IL-2), the principal cytokine responsible for progression of CD4(+) T-lymphocytes from the G1
Jipseol Jeong et al.
Veterinary immunology and immunopathology, 162(3-4), 154-161 (2014-12-03)
Interleukin (IL)-2 and IL-15 receptor β (IL-2/15Rβ, CD122) play important roles in signal transduction for biological functions of IL-2 and IL-15. We found that ducks possess three different IL-2/15Rβ transcripts, a conventional form (duIL-2/15Rβ) and two variants. Comparisons between the
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