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Merck

E9905

Sigma-Aldrich

Anti-Endothelin B Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Szinonimák:

Anti-ET-B Receptor

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

MDL-szám:
UNSPSC kód:
12352203
NACRES:
NA.41
klón:
polyclonal
application:
ICC
IHC (p)
faj reaktivitás:
human
technika/technikák:
immunocytochemistry: 4-11 μg/mL using human adrenal tissue
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-11 μg/mL using human adrenal tissue
citations:
7

biológiai forrás

rabbit

Minőségi szint

antitest forma

affinity isolated antibody

antitest terméktípus

primary antibodies

klón

polyclonal

Forma

buffered aqueous solution

faj reaktivitás

human

technika/technikák

immunocytochemistry: 4-11 μg/mL using human adrenal tissue
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 4-11 μg/mL using human adrenal tissue

UniProt elérési szám

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

Géninformáció

human ... EDNRB(1910)
mouse ... Ednrb(13618)
rat ... Ednrb(50672)

Immunogén

synthetic peptide corresponding to the N-terminal extracellular domain of human endothelin B receptor, conjugated to KLH. The immunizing peptide has 79% homology with the mouse gene and 84% homology with the rat gene.

Alkalmazás

Anti-Endothelin B Receptor antibody produced in rabbit is suitable for the following applications:
  • Immunocytochemistry at a concentration of 4-11μg/mL using human adrenal tissue
  • Immunohistochemistry (formalin-fixed, paraffin-embedded sections) at a concentration of 4-11μg/mL using human adrenal tissue
  • Western blotting
  • Immunofluorescence
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)

Biokémiai/fiziológiai hatások

EDNRB Endothelin receptor type B (ETB) is a protein encoded by the EDNRB gene in humans. It plays a pivotal role in oesophageal cancer and may act as a therapeutic target for this intractable malignancy. It has a novel role in oligodendroglioma proliferation and acts as a potential therapeutic alternative for oligodendrogliomas. Lower expression of ETB receptor responsiveness is associated with polycystic ovary syndrome (PCOS) and may reflect lower endothelial-mediated vasodilatation independent of generally lower vascular reactivity.

Fizikai forma

Solution in phosphate buffered saline, pH 7.7, containing 0.1% sodium azide.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

10 - Combustible liquids

WGK

nwg

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Amanda J Leblanc et al.
Microcirculation (New York, N.Y. : 1994), 20(5), 365-376 (2012-12-04)
The risk for cardiovascular disease increases with advancing age; however, the chronological development of heart disease differs in males and females. The purpose of this study was to determine whether age-induced alterations in responses of coronary arterioles to the endogenous
J Milara et al.
British journal of pharmacology, 161(7), 1599-1615 (2010-08-12)
Pulmonary arteries from smokers and chronic obstructive pulmonary disease patients show abnormal endothelium-dependent vascular reactivity. We studied the effect of cigarette smoke extract (CSE) on endothelin receptor B (ET(B) ) expression in human pulmonary artery endothelial cells (HPAECs) and its
Megan M Wenner et al.
The Journal of physiology, 589(Pt 19), 4671-4679 (2011-08-10)
Endothelin-1 is elevated in women with polycystic ovary syndrome (PCOS), and may play a role in the endothelial dysfunction associated with PCOS. Endothelin-1 binds two receptor subtypes, endothelin A (ET-A) and endothelin B (ET-B). We hypothesized that ET-A mediates vasoconstriction
Xin Wan et al.
Molecular medicine reports, 9(1), 229-234 (2013-10-23)
In this study, the role of the endothelin B receptor (ETBR) in oligodendroglioma cell proliferation and survival was investigated in vitro and in vivo. The overexpression and knockdown of ETBR was conducted in Hs683 human oligodendroglioma cells, and cell proliferation and activation (phosphorylation)
T Tanaka et al.
British journal of cancer, 110(4), 1027-1033 (2013-12-21)
The endothelin axis has been shown to have a pivotal role in several human malignancies. The aim of this study was to clarify the clinical importance of endothelin receptor type B (ETBR) in human oesophageal squamous cell carcinoma (OSCC). We

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