Összes fotó(1)
Fontos dokumentumok
E4531
Anti-ELKS antibody, Mouse monoclonal
clone ELKS-30, purified from hybridoma cell culture
Szinonimák:
Anti-KIAA1081
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
konjugátum:
unconjugated
application:
ARR
ICC
IP
WB
ICC
IP
WB
klón:
ELKS-30, monoclonal
faj reaktivitás:
rat, chicken, bovine, human, mouse
citations:
12
technika/technikák:
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.5-1 μg/mL using HeLa cell extract
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.5-1 μg/mL using HeLa cell extract
Javasolt termékek
biológiai forrás
mouse
konjugátum
unconjugated
antitest forma
purified immunoglobulin
antitest terméktípus
primary antibodies
klón
ELKS-30, monoclonal
Forma
buffered aqueous solution
molekulatömeg
antigen ~120 kDa
faj reaktivitás
rat, chicken, bovine, human, mouse
koncentráció
~2 mg/mL
technika/technikák
immunocytochemistry: suitable
immunoprecipitation (IP): suitable
microarray: suitable
western blot: 0.5-1 μg/mL using HeLa cell extract
izotípus
IgG2a
UniProt elérési szám
kiszállítva
dry ice
tárolási hőmérséklet
−20°C
célzott transzláció utáni módosítás
unmodified
Géninformáció
human ... ERC1(23085)
mouse ... Erc1(111173)
Related Categories
Általános leírás
ELKS/RAB6-interacting/CAST family member 1 is a protein encoded by the ERC1 gene in humans. It encodes for a synaptic factor and is found in the smallest region of overlap.
Monoclonal Anti-ELKS (mouse IgG2a isotype) is derived from the hybridoma ELKS-30 produced by the fusion of mouse myeloma cells (NS1 cells) and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human ELKS. ELKS, also known as KIAA1081, is an essential regulatory subunit of the IKK complex. It was named ELKS since 44.1% of the sequence is composed of glutamic acid (E), leucine (L), lysine (K) and serine (S) residues. The protein contains 948 amino acids with nine -helical coiled-coil domains including periodic heptad repeats that predict dimer formation. Its highest expression is in heart, placenta, lung, brain, thyroid and testis.
Alkalmazás
Monoclonal Anti-ELKS antibody produced in mouse has been used in:
- enzyme-linked immunosorbent assay (ELISA)
- fluorescence immunohistochemistry
- immunocytochemistry
- immunoblotting
Biokémiai/fiziológiai hatások
ELKS/RAB6-interacting/CAST family member 1 is a protein encoded by the ERC1 gene in humans. It encodes for a synaptic factor and is found in the smallest region of overlap. ERC1 encodes a regulator of neurotransmitter release and acts as the best gene candidate contributing to this phenotype as well as to the autism spectrum disorder ASD. ERC1a (an isoform of ERC1) is associated with other proteins for effective migration and tumor cell invasion by stabilizing the activity at the cell front. Depletion of any of the associated protein negatively affects invasion, migration on extracellular matrix, lamellipodial persistence and the internalization of active integrin β1 receptors needed for adhesion turnover at the front of the cell.
Fizikai forma
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
Jogi nyilatkozat
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Tárolási osztály kódja
10 - Combustible liquids
WGK
WGK 3
Lobbanási pont (F)
Not applicable
Lobbanási pont (C)
Not applicable
Egyéni védőeszköz
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Analitikai tanúsítványok (COA)
Lot/Batch Number
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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.
Fusion of a novel gene, ELKS, to RET due to translocation t (10; 12)(q11; p13) in a papillary thyroid carcinoma
Nakata T, et al.
Genes Chromosomes Cancer, 25(2), 97-103 (1999)
12p13.33 microdeletion including ELKS/ERC1, a new locus associated with childhood apraxia of speech.
Julien Thevenon et al.
European journal of human genetics : EJHG, 21(1), 82-88 (2012-06-21)
Speech sound disorders are heterogeneous conditions, and sporadic and familial cases have been described. However, monogenic inheritance explains only a small proportion of such disorders, in particular in cases with childhood apraxia of speech (CAS). Deletions of <5 Mb involving
Jie Chen et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 31(2), 512-525 (2011-01-14)
Synapse formation requires the organization of presynaptic active zones, the synaptic vesicle release sites, in precise apposition to postsynaptic neurotransmitter receptor clusters; however, the molecular mechanisms responsible for these processes remain unclear. Here, we show that P/Q-type and N-type voltage-dependent
Wei Wang et al.
The Journal of biological chemistry, 290(21), 13372-13385 (2015-04-12)
DNA damage-induced NF-κB activation plays a critical role in regulating cellular response to genotoxic stress. However, the molecular mechanisms controlling the magnitude and duration of this genotoxic NF-κB signaling cascade are poorly understood. We recently demonstrated that genotoxic NF-κB activation
Dillon Jevon et al.
eLife, 11 (2022-05-14)
A developing understanding suggests that spatial compartmentalisation in pancreatic β cells is critical in controlling insulin secretion. To investigate the mechanisms, we have developed live-cell subcellular imaging methods using the mouse organotypic pancreatic slice. We demonstrate that the organotypic pancreatic
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