AV33672

Anti-NR1H4 antibody produced in rabbit

affinity isolated antibody

• Szinonimák: Anti-Nuclear receptor subfamily 1, group H, member 4
• UNSPSC kód: 12352203
• NACRES: NA.41

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• konjugátum: unconjugated
• antitest forma: affinity isolated antibody
• antitest terméktípus: primary antibodies
• klón: polyclonal
• Forma: buffered aqueous solution
• molekulatömeg: 54 kDa
• faj reaktivitás: guinea pig, horse, bovine, rat, human, mouse, dog
• koncentráció: 0.5 mg - 1 mg/mL
• technika/technikák: immunohistochemistry: suitable; western blot: suitable
• NCBI elérési szám: NP_005114
• UniProt elérési szám: Q96RI1-2
• kiszállítva: wet ice
• tárolási hőmérséklet: −20°C
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... NR1H4(9971)

Leírás

Általános leírás

Farnesoid X receptor (FXR/NR1H4) belongs to the nuclear receptor (NR) superfamily. It is a receptor of bile acids (BAs). FXR is expressed in liver, intestine, kidney and adrenal gland. This gene is located on human chromosome 12q23. It has n N-terminal DNA binding domain (DBD) and the C-terminal ligand binding domain (LBD).

Immunogén

Synthetic peptide directed towards the middle region of human NR1H4

Biokémiai/fiziológiai hatások

The NR1H4 gene encodes a protein that has a central role in lipid homeostasis and also regulates carbohydrate metabolism.

The ligand-activated transcription factor farnesoid X receptor (FXR/NR1H4) plays a key role in metabolic regulation and liver protection. FXR modulates bile acid, lipid and glucose metabolism. It participates in the modulation of bile acid synthesis, secretion and transport. Mutation in this gene results in familial intrahepatic cholestasis.

Szekvencia

Synthetic peptide located within the following region: AECLLTEIQCKSKRLRKNVKQHADQTVNEDSEGRDLRQVTSTTKSCREKT

Fizikai forma

Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable