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Merck
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Fontos dokumentumok

348M-9

Sigma-Aldrich

WT1 (6F-H2) Mouse Monoclonal Antibody

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Összes fotó(1)

About This Item

UNSPSC kód:
12352203
NACRES:
NA.41

biológiai forrás

mouse

Minőségi szint

100
500

konjugátum

unconjugated

antitest forma

culture supernatant

antitest terméktípus

primary antibodies

klón

6F-H2, monoclonal

leírás

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

faj reaktivitás

human

kiszerelés

vial of 0.1 mL concentrate (348M-94)
vial of 0.5 mL concentrate (348M-95)
bottle of 1.0 mL predilute (348M-97)
vial of 1.0 mL concentrate (348M-96)
bottle of 7.0 mL predilute (348M-98)

gyártó/kereskedő neve

Cell Marque™

technika/technikák

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

izotípus

IgG1κ

szabályozó

kidney, mesothelioma, ovarian carcinoma (serous), testis

kiszállítva

wet ice

tárolási hőmérséklet

2-8°C

vizualizáció

nuclear

Géninformáció

human ... WT1(7490)

Általános leírás

Wilms’ tumor 1 protein (WT1) is a zinc finger transcription factor, normally expressed intissues of mesodermal origin. The Wilms’ tumor gene encodes a protein that functionsas a tumor suppressor gene mapped to human chromosome 11p13.2 Nuclear WT1immunoreactivity has been observed in high frequencies in several types of mesoderm-derived tumors including epithelioid mesothelioma and ovarian serous carcinoma and thus isused as a marker for these neoplasms.

Minőség


IVD
IVD
IVD
RUO

Kapcsolódás

WT-1 Positive Control Slides, Product No. 348S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Fizikai forma

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Elkészítési megjegyzés

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Egyéb megjegyzések

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Jogi információk

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Dokumentumtár megtekintése

Martin Köbel et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 35(5), 430-441 (2016-03-15)
There are 5 major histotypes of ovarian carcinomas. Diagnostic typing criteria have evolved over time, and past cohorts may be misclassified by current standards. Our objective was to reclassify the recently assembled Canadian Ovarian Experimental Unified Resource and the Alberta
Sarah K Galfione et al.
International journal of clinical and experimental pathology, 7(5), 2536-2543 (2014-06-27)
Vascular lesions are commonly encountered in routine pathologic practice and often pose diagnostic challenges owing to their morphologic diversity. Although WT-1 expression was reported in some vascular tumors, little is known about its staining patterns in a spectrum of vascular
Hadi Yaziji et al.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, 19(4), 514-523 (2006-03-24)
We evaluated the sensitivity and specificity of 10 monoclonal and two polyclonal antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma (AdCA) using immunohistochemistry (IHC). The antibodies were directed against the mesothelial-associated antigens mesothelin, calretinin, cytokeratin 5, thrombomodulin, Wilms' tumor-1 (WT-1) gene
Koji Tsuta et al.
Applied immunohistochemistry & molecular morphology : AIMM, 17(2), 126-130 (2009-06-12)
Malignant pleural mesothelioma (MPM) is known to mimic the morphology of a number of diverse neoplastic conditions. WT-1 protein is conventionally used as a positive mesothelioma marker. Recently, a new monoclonal antibody clone WT49 has recently become commercially available. To
Alberto M Marchevsky
Archives of pathology & laboratory medicine, 132(3), 397-401 (2008-03-06)
The diagnosis of malignant mesothelioma (MM) is rendered with the aid of immunohistochemistry to demonstrate the presence of "mesothelial," "epithelial," or "sarcomatous" differentiation. Antibody panels that have been proposed for the distinction between MM and other neoplasms usually include 2
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