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Merck
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Fontos dokumentumok

221M-1

Sigma-Aldrich

Annexin A1 (MRQ-3) Mouse Monoclonal Antibody

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)

About This Item

UNSPSC kód:
12352203
NACRES:
NA.41

biológiai forrás

mouse

Minőségi szint

100
500

konjugátum

unconjugated

antitest forma

culture supernatant

antitest terméktípus

primary antibodies

klón

MRQ-3, monoclonal

leírás

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

faj reaktivitás

human

kiszerelés

vial of 0.1 mL concentrate (221M-14)
vial of 0.5 mL concentrate (221M-15)
bottle of 1.0 mL predilute (221M-17)
vial of 1.0 mL concentrate (221M-16)
bottle of 7.0 mL predilute (221M-18)

gyártó/kereskedő neve

Cell Marque™

technika/technikák

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:100-1:500

izotípus

IgG1

szabályozó

hairy cell leukemia

kiszállítva

wet ice

tárolási hőmérséklet

2-8°C

vizualizáció

cytoplasmic, membranous

Related Categories

Általános leírás

ANXA1 is strongly expressed on the cell membrane and occasionally in the cytoplasm of tumor cells in 97% of samples from patients with hairy cell leukemia. By contrast, B-cell lymphomas other than hairy cell leukemia, including typical splenic lymphoma with villous lymphocytes and patients with variant hairy cell leukemia—as defined by current morphologic, phenotypic, and clinical criteria—are ANXA1-negative. In a study by Falini et al. ANXA1 immunodetection was 100% sensitive and specific for hairy cell leukemia. Normal B cells from different lympho-hemopoietic tissues were ANXA1-negative. In this study the expression of ANXA1 in myeloid cells, macrophages, or T-cell subset served as positive control. These findings validated the results of gene expression profiling in hairy cell leukemia at the protein level by showing that ANXA1 is consistently expressed in this type of leukemic disease, but not in other B-cell lymphomas. Of note is that negativity for ANXA1 was also present in patients with splenic lymphoma with villous lymphocytes, variant hairy cell leukemia, prolymphocytic leukemia, marginal zone and lymphoplasmacytoid lymphomas. Thus, ANXA1 is a molecule specific to hairy cell leukemia that can be used to differentiate this disease from other B-cell lymphomas. Wang et al. showed that high ANXA1 expression is frequent in esophageal and esophagogastric junction adenocarcinomas, is associated with more advanced pathologic T stage and the presence of distant metastasis, and is an independent prognostic factor for patient survival.
Associated products: TRAcP, T-bet.

Minőség


IVD
IVD
IVD
RUO

Kapcsolódás

Annexin A1 Positive Control Slides, Product No. 221S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Fizikai forma

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Elkészítési megjegyzés

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Egyéb megjegyzések

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Jogi információk

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

WGK 2

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Shu-Hua Xia et al.
Oncogene, 21(43), 6641-6648 (2002-09-21)
The development and progression of human cancer are believed to be due to the alterations of multiple genes or/and their protein products. For identifying the proteins associated with esophageal cancer, we analysed the protein profiles of 24 pairs of esophageal
Kinship structure and health-care improvement in sub-Saharan Africa.
Moses N Katabarwa et al.
Lancet (London, England), 363(9427), 2194-2194 (2004-06-29)
R Dreier et al.
Histochemistry and cell biology, 110(2), 137-148 (1998-08-28)
Annexins constitute a family of Ca2+- and phospholipid-binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. To elucidate a possible correlation of
Kim L Wang et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 12(15), 4598-4604 (2006-08-11)
Annexin A1 (ANXA1) is a calcium-binding protein involved in arachidonic acid metabolism and epidermal growth factor receptor tyrosine kinase pathway. ANXA1 has been implicated in early squamous cell carcinogenesis of esophagus and correlates with degree of tumor differentiation. However, the

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