Ugrás a tartalomra
Merck

R0900000

Rifamycin B

European Pharmacopoeia (EP) Reference Standard

Szinonimák:

Rifamycin impurity A

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Tapasztalati képlet (Hill-képlet):
C39H49NO14
CAS-szám:
Molekulatömeg:
755.80
Beilstein:
604953
UNSPSC kód:
41116107
NACRES:
NA.24

grade

pharmaceutical primary standard

API-család

rifamycin, rifampicin

gyártó/kereskedő neve

EDQM

alkalmazás(ok)

pharmaceutical (small molecule)

Formátum

neat

tárolási hőmérséklet

2-8°C

SMILES string

N1c2c(c3c(c4c(c(c3O)C)O[C@](O\C=C\[C@@H]([C@H]([C@H]([C@@H]([C@@H]([C@@H]([C@H]([C@H](\C=C\C=C(/C1=O)\C)C)O)C)O)C)OC(=O)C)C)OC)(C4=O)C)c(c2)OCC(=O)O)O

InChI

1S/C39H49NO14/c1-17-11-10-12-18(2)38(49)40-24-15-26(51-16-27(42)43)28-29(34(24)47)33(46)22(6)36-30(28)37(48)39(8,54-36)52-14-13-25(50-9)19(3)35(53-23(7)41)21(5)32(45)20(4)31(17)44/h10-15,17,19-21,25,31-32,35,44-47H,16H2,1-9H3,(H,40,49)(H,42,43)/b11-10+,14-13+,18-12-/t17-,19+,20+,21+,25-,31-,32+,35+,39-/m0/s1

Nemzetközi kémiai azonosító kulcs

SQTCRTQCPJICLD-KTQDUKAHSA-N

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Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Rifamycin B EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Tárolási osztály kódja

11 - Combustible Solids

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


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Analitikai tanúsítványok (COA)

Lot/Batch Number

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Dokumentumtár megtekintése

Prashant M Bapat et al.
Applied microbiology and biotechnology, 72(4), 662-670 (2006-03-15)
It is well-known that secondary metabolite production is repressed by excess nitrogen substrate available in the fermentation media. Although the nitrogen catabolite repression has been known, quantitative process models have not been reported to represent this phenomenon in complex medium.
A homologue of the Mycobacterium tuberculosis PapA5 protein, rif-orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.
Yeping Xiong et al.
Chembiochem : a European journal of chemical biology, 6(5), 834-837 (2005-03-26)
Zhi Hua Jin et al.
The Journal of general and applied microbiology, 48(6), 329-334 (2003-04-12)
An industrially applied rifamycin B-producing strain, Amycolatopsis mediterranei XC 1-02, was used for further screening. A special mutation and screening procedure was adopted to select a strain, which can alleviate the inhibition caused by both aromatic amino acid and p-hydroxybenzoic
Xuan-Tien Doan et al.
Journal of biotechnology, 132(2), 156-166 (2007-08-04)
Industrial production of antibiotics, biopharmaceuticals and enzymes is typically carried out via a batch or fed-batch fermentation process. These processes go through various phases based on sequential substrate uptake, growth and product formation, which require monitoring due to the potential
Jun Xu et al.
Archives of biochemistry and biophysics, 411(2), 277-288 (2003-03-08)
The gene rif orf14 in the rifamycin biosynthetic gene cluster of Amycolatopsis mediterranei S699, producer of the antitubercular drug rifamycin B, encodes a protein of 272 amino acids identified as an AdoMet: 27-O-demethylrifamycin SV methyltransferase. Frameshift inactivation of rif orf14

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