D2250000

Dinoprostone

European Pharmacopoeia (EP) Reference Standard

• Szinonimák: Prostaglandin E₂, (5Z,11α,13E,15S)-11,15-Dihydroxy-9-oxoprosta-5,13-dienoic acid, Dinoprostone, PGE₂
• Tapasztalati képlet (Hill-képlet): C₂₀H₃₂O₅
• CAS-szám: 363-24-6
• Molekulatömeg: 352.47
• Beilstein: 4709356
• MDL-szám: MFCD00077861
• UNSPSC kód: 41116107
• PubChem Substance ID: 329798733
• NACRES: NA.24

Tulajdonságok

• grade: pharmaceutical primary standard
• API-család: dinoprostone
• gyártó/kereskedő neve: EDQM
• alkalmazás(ok): pharmaceutical (small molecule)
• format: neat
• SMILES string: O[C@@H]1CC([C@H](C/C=C\CCCC(O)=O)[C@H]1/C=C/[C@@H](O)CCCCC)=O
• InChI: 1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18(22)14-19(17)23)10-7-4-5-8-11-20(24)25/h4,7,12-13,15-17,19,21,23H,2-3,5-6,8-11,14H2,1H3,(H,24,25)/b7-4-,13-12+/t15-,16+,17+,19+/m0/s1
• Nemzetközi kémiai azonosító kulcs: XEYBRNLFEZDVAW-ARSRFYASSA-N
• Géninformáció: human ... PTGER1(5731) , PTGER2(5732) , PTGER3(5733) , PTGER4(5734)

Leírás

Általános leírás

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Alkalmazás

Dinoprostone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Biokémiai/fiziológiai hatások

Most biologically active prostaglandin. PGE₂ induces cervical ripening and parturition; mediates bradykinin-induced vasodilation; regulates adenylyl cyclase. Tumor cells that over-express cyclooxygenase 2 display increased invasiveness, angiogenesis, and resistance to apoptosis that may be due to the PGE₂-induced expression of angiogenic factors and stabilization of the anti-apoptotic protein, survivin.The effect of PGE₂ on the immune system is mixed. It inhibits T cell activation in vitro, suggesting it is an immunosuppressant. However, in vivo, it appears to effect expansion of the Th17 subset and differentiation of the Th1 subset of T helper cells, marking it as an immunoactivator.

Kiszerelés

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Egyéb megjegyzések

Sales restrictions may apply.

Biztonsági adatok

• Piktogramok: GHS08,GHS07
• Figyelmeztetés: Danger
• Figyelmeztető mondatok: H302,H360FD
• Óvintézkedésre vonatkozó mondatok: P202 - P264 - P280 - P301 + P312 - P308 + P313 - P405
• Veszélyességi osztályok: Acute Tox. 4 Oral - Repr. 1B
• Tárolási osztály kódja: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3