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Merck
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Fontos dokumentumok

MABN92

Sigma-Aldrich

Anti-Iba1/AIF1 Antibody

clone 20A12.1, from mouse

Szinonimák:

Allograft inflammatory factor 1, AIF-1, Ionized calcium-binding adapter molecule 1, Protein G1

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41
klón:
20A12.1, monoclonal
application:
IHC
WB
faj reaktivitás:
rat, mouse, human
technika/technikák:
immunohistochemistry: suitable
western blot: suitable
citations:
152

biológiai forrás

mouse

Minőségi szint

antitest forma

purified antibody

antitest terméktípus

primary antibodies

klón

20A12.1, monoclonal

faj reaktivitás

rat, mouse, human

kiszerelés

antibody small pack of 25 μg

technika/technikák

immunohistochemistry: suitable
western blot: suitable

izotípus

IgG1κ

NCBI elérési szám

UniProt elérési szám

kiszállítva

ambient

tárolási hőmérséklet

2-8°C

célzott transzláció utáni módosítás

unmodified

Géninformáció

human ... AIF1(199)

Általános leírás

The allograft inflammatory factor-1 (AIF-1) is a 17 kDa interferon-gamma (IFN-gamma) inducible Ca(2+)-binding EF-hand protein that is encoded within the HLA class III genomic region. AIF-1 is known to be identical with ionized Ca(2+)-binding adaptor 1, microglia response factor-1, and daintain. AIF-1 expression is mostly limited to the macrophage/monocyte lineage, and is augmented by cytokines, such as IFN-gamma. It is reported to be involved in neuronal function, inflammatory responses, allograft rejection, autoimmunity, and the activation and function of macrophages. It is also shown to be expressed in macrophages and microglial cells in autominnume disesases such as experimental autoimmune encephalomyelitis, and neuritis and uveitis models.

Immunogén

Linear peptide corresponding to human Iba1/AIF1.

Alkalmazás

Anti-Iba1/AIF1 Antibody is an antibody against Iba1/AIF1 for use in WB, IH.
Research Category
Neuroscience
Research Sub Category
Developmental Neuroscience
Western Blot Analysis: 1 µg/mL from a representative lot detected Iba1/AIF1 in 10 µg of mouse thymus tissue lysate.

Western Blot Analysis: 1 µg/mL from a representative lot detected Iba1/AIF1 in 10 µg of rat thymus tissue lysate.

Immunohistochemistry Analysis: A 1:300 dilution from a representative lot detected Iba/AIF1 in human spleen tissue.
Immunohistochemistry Analysis: A 1:1000 dilution from a representative lot detected Iba/AIF1 in rat spleen tissue

Minőség

Evaluated in Western Blot in human thymus tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected Iba1/AIF1 in 10 µg of human thymus tissue lysate.

Cél megnevezése

~17 kDa observed

Fizikai forma

Format: Purified
Protein G Purified
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Tárolás és stabilitás

Stable for 1 year at 2-8°C from date of receipt.

Analízis megjegyzés

Control
Human thymus tissue lysate

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Macrophage Ablation Reduces M2-Like Populations and Jeopardizes Tumor Growth in a MAFIA-Based Glioma Model.
Gabrusiewicz, K; Hossain, MB; Cortes-Santiago, N; Fan, X; Kaminska, B; Marini, FC; Fueyo et al.
Neoplasia null
Barbara D'Angelo et al.
Neuropharmacology, 101, 13-23 (2015-09-20)
Hypoxic-ischaemic (HI) injury is an important cause of neurological morbidity in neonates. HI leads to pathophysiological responses, including inflammation and oxidative stress that culminate in cell death. Activation of glycogen synthase kinase 3β (GSK3β) and the signal transducer and activator
Rachel Waller et al.
PloS one, 14(1), e0210888-e0210888 (2019-01-27)
Deep subcortical lesions (DSCL) of the brain, are present in ~60% of the ageing population, and are linked to cognitive decline and depression. DSCL are associated with demyelination, blood brain barrier (BBB) dysfunction, and microgliosis. Microglia are the main immune
Chi-Hua Guo et al.
International journal of molecular medicine, 38(5), 1433-1442 (2016-12-28)
Bone cancer pain (BCP) is one of the most difficult and intractable tasks for pain management, which is associated with spinal 'neuron-astrocytic' activation. The activation of the c-Jun N-terminal kinase (JNK)/chemokine (C-C motif) ligand (CCL2) signaling pathway has been reported to be critical
Kuan-I Lee et al.
Journal of neuroinflammation, 13(1), 92-92 (2016-04-29)
Transient receptor potential ankyrin 1 (TRPA1) channel plays an important role in pain and inflammation. However, little is known about the significance of the TRPA1 channel in the pathophysiology of Alzheimer's disease (AD). Wild-type (WT), TRPA1(-/-), amyloid precursor protein (APP)/presenilin

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