AB9744

Anti-14-3-3 τ (tau) Antibody

serum, Chemicon^®

• UNSPSC kód: 12352203
• eCl@ss: 32160702
• NACRES: NA.41
• klón: polyclonal
• application: ELISA; IHC; WB
• faj reaktivitás: rabbit, rat, bovine, sheep, mouse, human, chicken
• technika/technikák: ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• citations: 3

Tulajdonságok

• biológiai forrás: rabbit
• Minőségi szint: 100
• antitest forma: serum
• antitest terméktípus: primary antibodies
• klón: polyclonal
• faj reaktivitás: rabbit, rat, bovine, sheep, mouse, human, chicken
• gyártó/kereskedő neve: Chemicon^®
• technika/technikák: ELISA: suitable; immunohistochemistry: suitable; western blot: suitable
• NCBI elérési szám: NM_006826.2
• UniProt elérési szám: P27348
• kiszállítva: dry ice
• célzott transzláció utáni módosítás: unmodified
• Géninformáció: human ... YWHAQ(10971)

Leírás

Általános leírás

Mammals express seven distinct 14-3-3 isoforms (gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo- and hetero- dimmers, thus rendering 14-3-3 as a key multifunctional regulatory molecule. 14-3-3 isomers have been implicated in several neurological disorders: for example isoforms gamma, epsilon and beta are expressed in the cerebrospinal fluid of Creutzfeldt-Jakob patients, but not patients suffering from other neurological conditions such as Alzheimer′s.

The 14-3-3 tau antibody is one of a panel of antibodies that were generated against 14-3-3 isoforms and have demonstrated their potential for use as an ELISA-based diagnostic tool. These antibodies will allow the research to investigate the role of this protein in key cellular processes and neurological disorders such as Creutzfeldt-Jakob, Alzheimer′s and Parkinson′s Disease.

Egyediség

14-3-3 tau (theta). By Western blot the antibody recognizes the ~30 kDa protein.

Immunogén

Synthetic peptide from the N-terminal area of sheep 14-3-3 tau.

Alkalmazás

Detect 14-3-3 τ (tau) using this Anti-14-3-3 τ (tau) Antibody validated for use in ELISA, WB, IH.

Western blot: 1:3,000 using ECL.
Immunohistochemistry: 1:30-1:60 on mouse brain tissue which was treated by hydrated autoclaving at 121°C for 15 minutes prior to immunolabeling. Endogenous peroxidase was blocked with hydrogen peroxide in methanol and non-specific labeling with normal goat serum at 1:20 for 5 minutes.
ELISA
Optimal working dilutions must be determined by end user.

Cél megnevezése

30 kDa

Jogi információk

CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 1
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable