400088

HIF-1α Translation Inhibitor, KC7F2

The HIF-1α Translation Inhibitor, KC7F2, also referenced under CAS 927822-86-4, controls the biological activity of HIF-1α. This small molecule/inhibitor is primarily used for Cell Structure applications.

• Szinonimák: HIF-1α Translation Inhibitor, KC7F2, Hypoxia-Inducible Factor-1α Translation Inhibitor, KC7F2, N,Nʹ-(2,5-Dichlorosulfonyl)cystamine, HIF Inhibitor III
• Tapasztalati képlet (Hill-képlet): C₁₆H₁₆Cl₄N₂O₄S₄
• CAS-szám: 927822-86-4
• Molekulatömeg: 570.38
• MDL-szám: MFCD22683809
• UNSPSC kód: 12352200
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95% (HPLC)
• Forma: solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; protect from light
• szín: beige to tan
• oldhatóság: DMSO: 100 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: −20°C
• SMILES string: [S](=O)(=O)(NCCSSCCN[S](=O)(=O)c2c(ccc(c2)Cl)Cl)c1c(ccc(c1)Cl)Cl
• InChI: 1S/C16H16Cl4N2O4S4/c17-11-1-3-13(19)15(9-11)29(23,24)21-5-7-27-28-8-6-22-30(25,26)16-10-12(18)2-4-14(16)20/h1-4,9-10,21-22H,5-8H2
• Nemzetközi kémiai azonosító kulcs: REQLACDIZMLXIC-UHFFFAOYSA-N

Leírás

Általános leírás

A cell-permeable symmetrical cystamine compound that selectively suppresses cellular HIF-1α, but not HIF-1β, protein synthesis without affecting the transcription of HIF-1α mRNA or the stability of HIF-1α protein. Reduction of cellular HIF-1α by KC7F2 treatment (IC₅₀<20 µM in LN229 cultures under hypoxia condition) is shown to result in decreased transcriptions of HIF-1α-dependent genes, such as CA IX, endothelin 1, enolase 1, and MMP-2. Inhibition of 4EBP1 and S6K phosphorylation, important event for the initiation of protein translation, is also observed in KC7F2 and U87MGD cultures following KC7F2 treatment under hypoxia condition, which may account for, at least in part, the downregulated HIF-1α synthesis.

Kiszerelés

Packaged under inert gas

Figyelmeztetés

Toxicity: Standard Handling (A)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Egyéb megjegyzések

Narita, T., et al. 2009. Clin. Cancer Res.15, 6128.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable