233552-M

Cobra Venom Factor, Naja naja kaouthia

Cobra Venom Factor, Naja naja kaouthia, is a native cobra venom factor. Glycoprotein composed of three non-identical disulfide-bonded subunits of 68, 48, and 30 kDa.

• Szinonimák: Cobra Venom Anticomplementary Protein
• UNSPSC kód: 12352202

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥95% (SDS-PAGE)
• Forma: liquid
• specifikus aktivitás: ≥250 units/mL
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze; avoid repeated freeze/thaw cycles
• idegen aktivitás: Phospholipase, none detected
• tárolási hőmérséklet: −70°C

Leírás

Általános leírás

Native cobra venom factor from Naja naja kaouthia. Glycoprotein composed of three non-identical disulfide-bonded subunits with M.W. of 68 kDa (α), 48 kDa (β), and 30 kDa (γ). Cobra venom factor (CVF) is a structural and functional analog of cobra, as well as mammalian C3. Thus, in the presence of Factor B, Factor D, and Mg²⁺, CVF can form a stable CVF,Bb complex that is a C3/C5 convertase enzyme; however, the CVF,Bb complex is not susceptible to regulation by Factors H and I. Four to six µg of purified CVF are equal to 1.0 unit of functional activity as measured by the method of Cochrane, et al.

Native cobra venom factor from Naja naja kaouthia. Glycoprotein composed of three nonidentical disulfide-bound subunits with M.W. of 68,000 (α), 48,000 (β), and 30,000 (γ). Cobra Venom Factor (CVF) is a structural and functional analog of cobra, as well as mammalian C3. In the presence of Factor B, Factor D, and Mg²⁺, CVF can form a stable CVF, Bb complex which is a C3/C5 convertase enzyme; however, the CVF,Bb complex is not susceptible to regulation by Factors H and I. Four to six µg of purified CVF is equal to 1.0 unit of functional activity as measured by the method of Cochrane, et al.

Figyelmeztetés

Toxicity: Harmful (C)

Egyéb megjegyzések

Bogers, W.M., et al. 1993. Eur. J. Immunol.23, 433.
Fritzinger, D.C., et al. 1992. J. Immunol. 149, 3554.
Muller, B. and Muller-Ruchholtz, W. 1987. Leuk. Res.11, 461.
Vogel, C.W. and Muller-Eberhard, H.J. 1984. J. Immunol. Methods73, 203.
Cochrane, C.G., et al. 1970. J. Immunol. 105, 55.
Ballows, M. and Cochrane, C.G. 1969. J. Immunol.103, 944.

Jogi információk

Not available for sale outside the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 12 - Non Combustible Liquids
• WGK: WGK 2
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable