196870
BAY 11-7082
≥98% (HPLC), solid, NF-kB/TNF-α inhibitor, Calbiochem
Szinonimák:
BAY 11-7082, (E)3-[(4-Methylphenyl)sulfonyl]-2-propenenitrile
Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(1)
About This Item
Tapasztalati képlet (Hill-képlet):
C10H9NO2S
CAS-szám:
Molekulatömeg:
207.25
MDL-szám:
UNSPSC kód:
12352200
NACRES:
NA.77
Javasolt termékek
Terméknév
BAY 11-7082, The BAY 11-7082, also referenced under CAS 19542-67-7, controls the biological activity of TNF-α. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.
Minőségi szint
Teszt
≥98% (HPLC)
Forma
solid
gyártó/kereskedő neve
Calbiochem®
tárolási körülmény
OK to freeze
protect from light
szín
off-white
oldhatóság
DMSO: 200 mg/mL
kiszállítva
ambient
tárolási hőmérséklet
2-8°C
SMILES string
[S](=O)(=O)(c1ccc(cc1)C)\C=C\C#N
InChI
1S/C10H9NO2S/c1-9-3-5-10(6-4-9)14(12,13)8-2-7-11/h2-6,8H,1H3/b8-2+
Nemzetközi kémiai azonosító kulcs
DOEWDSDBFRHVAP-KRXBUXKQSA-N
Általános leírás
Potential anti-inflammatory agent that selectively and irreversibly inhibits the TNF-α-inducible phosphorylation of IκBα (IC50 = 10 µM), resulting in a decreased expression of NF-κB and of adhesion molecules. Does not affect constitutive IκBα autophosphorylation. Inhibits TNF-α-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. A 100 mM (10 mg/483 µl) solution of BAY 11-7082 (Cat. No. 196871) in DMSO is also available is also available.
Potential anti-inflammatory agent. Selectively and irreversibly inhibits the TNFα-inducible phosphorylation of IκB-α (IC50 = 10 µM) without affecting the constitutive IκB-α phosphorylation. Decreases nuclear translocation of NFκB and inhibits TNFα-induced surface expression of the endothelial-leukocyte cell adhesion molecules E-selectin, VCAM-1, and ICAM-1. E-selectin inhibition was shown to be irreversible (IC50 ~10 µM). Also reversibly increased the activity of p38 kinase and JNK-1 and stimulated tyrosine phosphorylation of a 130-140 kDa protein.
Biokémiai/fiziológiai hatások
Cell permeable: yes
Primary Target
TNF-α-inducible phosphorylation of IκBα
TNF-α-inducible phosphorylation of IκBα
Reversible: no
Target IC50: 10 µM inhibiting TNF-α-inducible phosphorylation of IκBα
Kiszerelés
Packaged under inert gas
Figyelmeztetés
Toxicity: Standard Handling (A)
Feloldás
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Egyéb megjegyzések
Kamthong PJ. and Wu, M-C. 2001. Biochem. J. 356.
Izban, K.F., et al. 2000. Hum. Pathol.31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
Izban, K.F., et al. 2000. Hum. Pathol.31, 1482.
Pierce, J.W., et al. 1997. J. Biol. Chem. 272, 21096.
Jogi információk
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Tárolási osztály kódja
11 - Combustible Solids
WGK
WGK 3
Analitikai tanúsítványok (COA)
Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.
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