178278

Apigenin

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM).

• Szinonimák: Apigenin, 4ʹ,5,7-Trihydroxyflavone
• Tapasztalati képlet (Hill-képlet): C₁₅H₁₀O₅
• CAS-szám: 520-36-5
• Molekulatömeg: 270.24
• MDL-szám: MFCD00006831
• UNSPSC kód: 12352212
• NACRES: NA.77

Tulajdonságok

• Minőségi szint: 100
• Teszt: ≥98% (HPLC)
• form: crystalline solid
• gyártó/kereskedő neve: Calbiochem^®
• tárolási körülmény: OK to freeze
• szín: yellow
• oldhatóság: hot ethanol: 1 mg/mL; DMSO: 10 mg/mL
• kiszállítva: ambient
• tárolási hőmérséklet: 2-8°C
• InChI: 1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
• Nemzetközi kémiai azonosító kulcs: KZNIFHPLKGYRTM-UHFFFAOYSA-N

Leírás

Általános leírás

A plant flavonoid that reverses the transformed phenotypes of various ras-transformed cells, apparently due to inhibition of mitogen activated protein (MAP) kinase-associated signal transduction pathways. Treatment of v-H-ras-transformed NIH 3T3 cells with apigenin (12.5 µM) has been shown to induce dephosphorylation of p44^mapk and reduction in MAP kinase activity. Has also been reported to inhibit the proliferation of malignant tumor cells by G₂/M arrest and to induce morphological differentiation.

Induces the reversion of transformed phenotypes of v-H-ras-transformed NIH 3T3 cells at low concentration (12.5 µM). This finding has been attributed to the inhibition of MAP kinase activity. Inhibits the proliferation of malignant tumor cells by G₂/M arrest and induces morphological differentiation.

Biokémiai/fiziológiai hatások

Cell permeable: no

Primary Target
MAP kinase

Product does not compete with ATP.

Reversible: no

Figyelmeztetés

Toxicity: Irritant (B)

Feloldás

Following reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 4 months at -20°C.

Egyéb megjegyzések

Kuo, M.L., and Yang, N.C. 1995. Biochem. Biophys. Res. Commun.212, 767.
Chaumontet, C., et al. 1994. Carcinogenesis 15, 2325.
Kuo, M.L., et al. 1994. Cancer Lett.87, 91.
Sato, F., et al. 1994. Biochem. Biophys. Res. Commun.204, 578.

Jogi információk

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Biztonsági adatok

• Tárolási osztály kódja: 11 - Combustible Solids
• WGK: WGK 3