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Merck
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Fontos dokumentumok

07-1341

Sigma-Aldrich

Anti-PHLPP1 Antibody

from rabbit, purified by affinity chromatography

Szinonimák:

PH domain and leucine rich repeat protein phosphatase, PH domain leucine-rich repeat protein phosphatase, Pleckstrin homology domain-containing family E protein 1, SCN circadian oscillatory protein, Suprachiasmatic nucleus circadian oscillatory protein

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez
Összes fotó(3)

About This Item

UNSPSC kód:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biológiai forrás

rabbit

Minőségi szint

100

konjugátum

conjugate

antitest forma

affinity isolated antibody

antitest terméktípus

primary antibodies

klón

polyclonal

form

liquid

tisztítva

affinity chromatography

faj reaktivitás

rat, mouse, human

technika/technikák

immunocytochemistry: suitable
western blot: suitable

immunogén szekvencia

KLH-conjugated linear peptide corresponding to the C-terminus of PHLPP1.

NCBI elérési szám

NP_919431

UniProt elérési szám

O60346

kiszállítva

wet ice

tárolási hőmérséklet

2-8°C

Géninformáció

human ... PHLPP1(23239)

Általános leírás

PHLPP1 is the protein phosphatase responsible for dephosphorylation of the Akt (Ser473) site. Akt (Ser473) is the TORC2 (mTOR) phosphorylation activation site.

Egyediség

This antibody recognizes the C-terminal region of PHLPP1.

Immunogen

Epitope: C-terminus
KLH-conjugated linear peptide corresponding to the C-terminus of PHLPP1.

Alkalmazás

Anti-PHLPP1 Antibody detects level of PHLPP1 & has been published & validated for use in WB & IC.
Research Category
Signaling
Research Sub Category
PI3K, Akt, & mTOR Signaling

Minőség

Evaluated by Western Blot in Human brain tissue lysate.
Western Blot Analysis: A 1:1,000 dilution of this antibody detected PHLPP1 in Human brain tissue lysate.

Cél megnevezése

134 kDa Observed at 110 kDa

Fizikai forma

Affinity purified
Purified rabbit serum in buffer containing 0.1 M Tris-glycine, pH 7.4, 150 mM NaCl and 0.05% sodium azide.

Tárolás és stabilitás

Maintain refrigerated at 2-8°C for 1 year from date of receipt.

Analízis megjegyzés

Control
Human brain tissue lysate

Egyéb megjegyzések

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

Jogi nyilatkozat

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Tárolási osztály kódja

12 - Non Combustible Liquids

WGK

WGK 1

Lobbanási pont (F)

Not applicable

Lobbanási pont (C)

Not applicable

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

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Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Saida Abdelli et al.
PloS one, 7(5), e35997-e35997 (2012-05-09)
We have recently shown that silencing of the brain/islet specific c-Jun N-terminal Kinase3 (JNK3) isoform enhances both basal and cytokine-induced beta-cell apoptosis, whereas silencing of JNK1 or JNK2 has opposite effects. While it is known that JNK1 or JNK2 may
Travis C Jackson et al.
Scientific reports, 5, 9377-9377 (2015-04-02)
Pleckstrin homology domain and leucine rich repeat protein phosphatase 1 (PHLPP1) is a member of the serine/threonine family of phosphatases. It has been studied in organs including brain, heart, pancreas, adipose, breast, and prostate. Human PHLPP1 encodes two splice variants
Marcelline K Hanson et al.
PloS one, 16(6), e0251732-e0251732 (2021-06-19)
Prior studies demonstrated that deletion of the protein phosphatase Phlpp1 in Ctsk-Cre expressing cells enhances bone mass, characterized by diminished osteoclast activity and increased coupling to bone formation. Due to non-specific expression of Ctsk-Cre, the definitive mechanism for this observation
Julia Fischer et al.
Proceedings of the National Academy of Sciences of the United States of America, 116(33), 16551-16560 (2019-07-28)
The dynamic interplay between metabolism and immune responses in health and disease, by which different immune cells impact on metabolic processes, are being increasingly appreciated. However, the potential of master regulators of metabolism to control innate immunity are less understood.
Yovita Permata Budi et al.
PeerJ, 10, e13867-e13867 (2022-08-23)
Studies have observed changes in autophagic flux in the adipose tissue of type 2 diabetes patients with obesity. However, the role of autophagy in obesity-induced insulin resistance is unclear. We propose to confirm the effect of a high-fat diet (HFD)
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