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M-031

Supelco

Morphine-3-β-D-glucuronide solution

1 mg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

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Összes fotó(1)

About This Item

Tapasztalati képlet (Hill-képlet):
C23H27NO9
CAS-szám:
20290-09-9
Molekulatömeg:
461.46
MDL-szám:
MFCD00056773
UNSPSC kód:
41116107
PubChem Substance ID:
329817768
NACRES:
NA.24

grade

certified reference material

Minőségi szint

300

Forma

liquid

kiszerelés

ampule of 1 mL

gyártó/kereskedő neve

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

koncentráció

1 mg/mL in methanol with 0.05% NaOH

technika/technikák

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

alkalmazás(ok)

forensics and toxicology

Formátum

single component solution

tárolási hőmérséklet

2-8°C

SMILES string

O[C@@H](C=C1)[C@H]2[C@](C1[C@H]3C4)(CCN3C)C5=C4C=CC(O[C@H]6[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O6)=C5O2

InChI

1S/C23H27NO9/c1-24-7-6-23-10-3-4-12(25)20(23)32-18-13(5-2-9(14(18)23)8-11(10)24)31-22-17(28)15(26)16(27)19(33-22)21(29)30/h2-5,10-12,15-17,19-20,22,25-28H,6-8H2,1H3,(H,29,30)/t10?,11-,12+,15+,16+,17-,19+,20+,22-,23+/m1/s1

Nemzetközi kémiai azonosító kulcs

WAEXKFONHRHFBZ-RURUVCMVSA-N

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Általános leírás

A certified solution standard of Morphine-3-ß-D-glucuronide at a concentration of 1.0 mg/mL for high volumes of sample testing. This certified solution standard is suitable for LCMS or GCMS applications including forensic analysis or urine drug testing.

Alkalmazás


  • Morphine-3-β-ᴅ-glucuronide (M3G) Solution in Clinical Analysis: The use of M3G glucuronide standard in liquid chromatography-tandem mass spectrometry has been validated for quantifying analgesics and sedatives in human plasma, with applications in intensive care and neurological death determination studies. This underlines the solution′s critical role in pharmacokinetic research of morphine metabolites within pharmaceutical sciences (Jutras et al., 2020).

  • Opioid Metabolite Research with M3G: Analysis of opiate and opiate metabolites, including M3G, in urine after consumption of cold syrups by LC-MS/MS, emphasizes the solution′s importance in biochemical assays of morphine derivatives. This research is integral for monitoring drug abuse and optimizing therapeutic strategies in the pharma and biotech sectors (Yen YT et al., 2020).

  • Electrophoresis-based Determination of M3G: Capillary electrophoresis-mass spectrometry has determined morphine and its isobaric glucuronide metabolites, including M3G, as an essential biochemistry tool for studying opioid metabolism. Such methods enable accurate profiling of drug metabolism, serving both research and clinical diagnostic purposes (Isbell TA et al., 2015).

  • M3G Metabolism and UGT2B7 Enzyme: The catalysis of M3G glucuronidation and glucosidation by UDP-glucuronosyltransferase 2B7 highlights the solution′s use in uncovering complementary metabolic pathways of morphine. The findings have significant implications for the biochemist′s understanding of drug metabolism pathways in pharmaceutical research (Chau N et al., 2014).

  • Stability Assessment in Sewage Epidemiology: The stability of drug biomarkers, including M3G in municipal wastewater, influences the estimation of drug consumption. Using high-purity M3G solution as a research standard aids in sewage epidemiology and environmental monitoring (Senta I et al., 2014).


Jogi információk

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

kapcsolódó termék

Product No.
Leírás
Árazás

D-033

Dihydromorphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

E-052

Ethylmorphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

IMPM-005-05

10-Hydroxymorphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

IMPM-005-06

10-Oxomorphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-003

Morphine-D3 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-005

Morphine solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-006

Morphine-D3 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-017

Morphine-D3-3-β-D-glucuronide solution, 100 μg/mL in methanol with 0.05% NaOH, ampule of 1 mL, certified reference material, Cerilliant®

M-018

Morphine-3-β-D-glucuronide solution, 100 μg/mL in methanol: water ( 50:50(v/v)), ampule of 1 mL, certified reference material, Cerilliant®

M-030

Morphine solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-046

Morphine-6-β-D-glucuronide solution, 1.0 mg/mL in methanol: water (2:8), ampule of 1 mL, certified reference material, Cerilliant®

M-085

Morphine-D6 solution, 100 μg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-086

Morphine-D6 solution, 1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

M-096

Morphine-6-β-D-glucuronide solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

M-120

Morphine-6-β-D-glucuronide-D3 solution, 100 μg/mL in methanol: water (1:1), ampule of 1 mL, certified reference material, Cerilliant®

Figyelmeztetés

Danger

Figyelmeztető mondatok

H225,H301 + H311 + H331,H370

Veszélyességi osztályok

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Célzott szervek

Eyes,Central nervous system

Tárolási osztály kódja

3 - Flammable liquids

WGK

WGK 2

Lobbanási pont (F)

51.8 °F - closed cup

Lobbanási pont (C)

11 °C - closed cup

Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Michael R Due et al.
Journal of neuroinflammation, 9, 200-200 (2012-08-18)
Multiple adverse events are associated with the use of morphine for the treatment of chronic non-cancer pain, including opioid-induced hyperalgesia (OIH). Mechanisms of OIH are independent of opioid tolerance and may involve the morphine metabolite morphine-3-glucuronide (M3G). M3G exhibits limited
Maarten Swartjes et al.
Molecular medicine (Cambridge, Mass.), 18, 1320-1326 (2012-09-25)
Opioid-induced hyperalgesia (OIH) is a paradoxical increase in pain perception that may manifest during opioid treatment. For morphine, the metabolite morphine-3-glucuronide (M3G) is commonly believed to underlie this phenomenon. Here, in three separate studies, we empirically assess the role of
Yoshitaka Hasegawa et al.
The Journal of pharmacy and pharmacology, 62(3), 310-314 (2010-05-22)
The aim was to investigate the pharmacokinetics of morphine and its metabolite, morphine-3-glucuronide (M3G), in a rat model of streptozotocin (STZ)-induced diabetes. Morphine (15 mg/kg) was administered intravenously, and the concentrations of morphine and M3G in the plasma, urine and
Arief Nurrochmad et al.
Drug metabolism and pharmacokinetics, 25(3), 262-273 (2010-07-09)
The formation of morphine-3-glucuronide (M-3-G, pharmacologically inactive) and morphine-6-glucuronide (M-6-G, active metabolite) by liver microsomes from humans and rodents, including chimeric mice carrying human liver, was evaluated in the presence of fatty acyl-CoAs. Medium- to long-chain fatty acyl-CoAs, including oleoyl-CoAs
Shawn McCann et al.
Journal of opioid management, 6(2), 87-94 (2010-05-21)
The 3-glucuronide metabolites of morphine and hydromorphone have been implicated as a causative factor for patients exhibiting myoclonus. The primary goal of this study was to determine plasma levels of morphine-3-glucuronide (M3G) or hydromorphone-3-glucuronide (H3G) in patients demonstrating myoclonus and
View All Related Papers

Protocols

UHPLC/MS for Drug Detection in Urine

Optimize β-glucuronidase hydrolysis for glucuronide metabolite analysis considering factors like time, temperature, pH, and enzyme concentration.

Tudóscsoportunk valamennyi kutatási területen rendelkezik tapasztalattal, beleértve az élettudományt, az anyagtudományt, a kémiai szintézist, a kromatográfiát, az analitikát és még sok más területet.

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