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Merck

860042P

Avanti

16:0-d31-18:1 PI

1-palmitoyl-d31-2-oleoyl-sn-glycero-3-phosphoinositol (ammonium salt), powder

Szinonimák:

110923

Bejelentkezésa Szervezeti és Szerződéses árazás megtekintéséhez


About This Item

Tapasztalati képlet (Hill-képlet):
C43H53NO13PD31
CAS-szám:
Molekulatömeg:
885.29
UNSPSC kód:
51191904
NACRES:
NA.25

Teszt

>99% (TLC)

form

powder

kiszerelés

pkg of 1 × 100 μg (with stopper and crimp cap (860042P-100ug))
pkg of 1 × 500 μg (with stopper and crimp cap (860042P-500ug))

gyártó/kereskedő neve

Avanti Research - A Croda Brand 860042P

kiszállítva

dry ice

tárolási hőmérséklet

−20°C

SMILES string

[NH4+].[2H]C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C(=O)OC[C@H](COP([O-])(=O)O[C@H]1C(O)C(O)C(O)[C@@H](O)C1O)OC(=O)CCCCCCC\C=C/CCCCCCCC

Általános leírás

16:0-d31-18:1 PI or 1-palmitoyl-d31-2-oleoyl-sn-glycero-3-phosphoinositol is a deuterated phospholipid. This lipid consists of a phosphatidylinositol group attached to palmitic acid and oleic acid.
Deuterated fatty acids experience exchange of the deuteriums on the alpha carbon to the carbonyl, i.e., C2 position, and will therefore be a mixture of compounds that are fully deuterated and partially deuterated at that position.

Alkalmazás

16:0-d31-18:1 PI or 1-palmitoyl-d31-2-oleoyl-sn-glycero-3-phosphoinositol has been used as an internal standard:
  • in yeast lipid profiling
  • for the quantification of lipids using electrospray ionization tandem mass spectrometry (ESI-MS/MS)
  • for the extraction of lipids from human bronchus tissue and epithelium samples using Bligh and Dyer method and for liquid chromatography-mass spectrometry (LC-MS) analysis

Biokémiai/fiziológiai hatások

Phosphatidylinositol (PI) is phosphorylated at their hydroxyls group and the phosphorylated PIs regulate several biological processes including membrane trafficking, recruitment of proteins and autophagy.

Kiszerelés

2 mL Amber Serum Vial with Stopper and Crimp Cap (860042P-100ug)
2 mL Amber Serum Vial with Stopper and Crimp Cap (860042P-500ug)

Jogi információk

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Tárolási osztály kódja

11 - Combustible Solids


Analitikai tanúsítványok (COA)

Analitikai tanúsítványok (COA) keresése a termék sarzs-/tételszámának megadásával. A sarzs- és tételszámok a termék címkéjén találhatók, a „Lot” vagy „Batch” szavak után.

Már rendelkezik ezzel a termékkel?

Az Ön által nemrégiben megvásárolt termékekre vonatkozó dokumentumokat a Dokumentumtárban találja.

Dokumentumtár megtekintése

Nicholas J Blunsom et al.
Biochimica et biophysica acta. Molecular and cell biology of lipids, 1865(1), 158471-158471 (2019-06-08)
Phosphatidylinositol (PI) is a minor phospholipid with a characteristic fatty acid profile; it is highly enriched in stearic acid at the sn-1 position and arachidonic acid at the sn-2 position. PI is phosphorylated into seven specific derivatives, and individual species
Nicole Zehethofer et al.
Chromatographia, 78(5-6), 403-413 (2015-03-10)
Airway epithelial cells play an important role in the pathogenesis of inflammatory lung diseases such as asthma, cystic fibrosis and COPD. Studies concerning the function of the lipid metabolism of the airway epithelium are so far based only on the
Sarah Spiegel et al.
Nature reviews. Molecular cell biology, 4(5), 397-407 (2003-05-03)
The evolutionarily conserved actions of the sphingolipid metabolite, sphingosine-1-phosphate (S1P), in yeast, plants and mammals have shown that it has important functions. In higher eukaryotes, S1P is the ligand for a family of five G-protein-coupled receptors. These S1P receptors are
Michael Maceyka et al.
Trends in cell biology, 22(1), 50-60 (2011-10-18)
The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis. S1P is produced in cells by two sphingosine kinase isoenzymes, SphK1 and SphK2. Many cells
Michael Ter Braak et al.
Biochemical pharmacology, 81(5), 617-625 (2010-12-18)
Sphingosine-1-phosphate (S1P) acts as high affinity agonist at specific G-protein-coupled receptors, S1P(1-5), that play important roles e.g. in the cardiovascular and immune systems. A S1P receptor modulating drug, FTY720 (fingolimod), has been effective in phase III clinical trials for multiple

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