908843

Poly(lactide-co-glycolide)-b-poly(ethylene glycol)-b-poly(lactide-co-glycolide)

average M_n (1,600-1,500-1,600), lactide:glycolide 75:25

• Szinonimák: PLGA-PEG-PLGA
• Lineáris képlet: H((C₃H₄O₂)_x(C₂H₂O₂)_y)_m((C₂H₄O)_z)_nO((C₃H₄O₂)_x(C₂H₂O₂)_y)_mH
• UNSPSC kód: 51171641
• NACRES: NA.23

Tulajdonságok

• Forma: semisolid
• adagolási arány: lactide:glycolide 75:25
• molekulatömeg: PEG average M_n 1,500 (by NMR); PLGA average M_n 3,200 (by NMR); average M_n (1,600-1,500-1,600)
• szín: white to tan
• PDI: ≤2.0; <1.1 (Typical PEG PDI )
• tárolási hőmérséklet: −20°C

Leírás

Alkalmazás

PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs. Also this polymer exhibits thermogelation behavior. When applied in biomedical applications, the temperature responsive nature of the copolymer can be tuned to induce an in situ gelation at physiological temperature to provide controlled drug release. These materials have been explored for biomedical applications as temperature-responsive biodegradable systems for drug delivery, tissue engineering and wound healing.

Biztonsági adatok

• Tárolási osztály kódja: 10 - Combustible liquids
• WGK: nwg
• Lobbanási pont (F): Not applicable
• Lobbanási pont (C): Not applicable