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Merck

C7397

Sigma-Aldrich

Cyclophosphamid Monohydrat

ISOPAC®

Synonym(e):

2-[Bis-(2-chlorethyl)-amino]-tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxid, Cytoxan

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1 G
145,00 €

145,00 €


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1 G
145,00 €

About This Item

Empirische Formel (Hill-System):
C7H15Cl2N2O2P · H2O
CAS-Nummer:
Molekulargewicht:
279.10
Beilstein:
4678992
EG-Nummer:
MDL-Nummer:
UNSPSC-Code:
51112507
PubChem Substanz-ID:
NACRES:
NA.25

145,00 €


Versandbereit am09. April 2025Details


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Assay

97.0-103.0% (HPLC)

Form

powder

mp (Schmelzpunkt)

49-51 °C (lit.)

Lagertemp.

2-8°C

SMILES String

[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1

InChI

1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2

InChIKey

PWOQRKCAHTVFLB-UHFFFAOYSA-N

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Anwendung

Cyclophosphamide, a nitrogen mustard DNA alkylating agent, is used to study its mechanisms of action as an anticancer and antiimmunity drug.

Biochem./physiol. Wirkung

Cyclophosphamid ist ein Stickstofflostderivat, das in der Krebstherapie verbreitete Anwendung findet. Es führt zur Quervernetzung der DNA sowie zum Abbruch von Strängen und induziert Mutationen. Seine klinische Aktivität wird mit einer Abnahme der ALDH1-Aktivität (Aldehyd-Dehydrogenase 1) assoziiert.
Stickstofflostderivat, das in der Krebstherapie verbreitete Anwendung findet. Es führt zur Quervernetzung der DNA sowie zum Abbruch von Strängen und induziert Mutationen.

Verpackung

Packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal.

Vorsicht

Injecting a compatible solvent directly into the vial permits preparation of any desired strength solution without exposure.

Rekonstituierung

Dissolving the contents in 100 mL of solvent yields a 1% solution.

Rechtliche Hinweise

Isopac is a registered trademark of Merck KGaA, Darmstadt, Germany

ISOPAC von

Produkt-Nr.
Beschreibung
Preisangaben

Piktogramme

Skull and crossbonesHealth hazard

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges


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Fragen

1-4 von 4 Fragen  
  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 Antwort
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 Antwort
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How should stock solutions for item C7397-1G, Cyclophosphamide monohydrate be stored?

    1 Antwort
    1. The stock solution should be stored at 0 - 4°C for short-term use or at -20°C for long-term storage.

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  4. what is the difference between C7397 & C0768?

    1 Antwort
    1. Both Product C7397 and C0768 fall under the same Chemical Abstract Service number (CAS) 6055-19-2, which means chemically they are the same. Both products are also offered in a powdered format. These products are suitable for the application of cyclophosphamide.

      The differences between the two materials is that product C7397 is only offered in 1 gram pack size. It is also apart of the ISOPAC portfolio, which are products that are packaged in special packaging for sensitive and hazardous chemical. This product is specifically packaged in a 100 mL serum bottle with silicon/PTFE septum and aluminum tear seal. This specialized packaging allows for injection of a compatible solvent directly into the vial to any desired strength solution without exposure of the material to the air. Product C0768 is offered in 1 gram, 5 grams, 10 grams, and 25 grams. All pack sizes are packaged in a glass bottle and bulk packaging is an available option for this material.

      Product C7397 has a quality level of 100 while product C0768 has a quality level of 200. Products with quality level 100 are designed for non-regulated applications with no change notification requirements. Products with quality level of 200 are designed for non-regulated applications with limited change notification requirements.

      The specifications for each product are slightly different as well, please view the specification sheets for both items:
      https://www.sigmaaldrich.com/specification-sheets/473/595/C7397-BULK________SIGMA____.pdf
      https://www.sigmaaldrich.com/specification-sheets/989/258/C0768-BULK________SIGMA____.pdf

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