PHR1404

Cyclophosphamid Monohydrat

Pharmaceutical Secondary Standard; Certified Reference Material

• Synonym(e): 2-[Bis-(2-chlorethyl)-amino]-tetrahydro-2H-1,3,2-oxazaphosphorin-2-oxid, Cytoxan
• Empirische Formel (Hill-System): C₇H₁₅Cl₂N₂O₂P · H₂O
• CAS-Nummer: 6055-19-2
• Molekulargewicht: 279.10
• Beilstein: 4678992
• EG-Nummer: 200-015-4
• MDL-Nummer: MFCD00149395
• UNSPSC-Code: 41116107
• PubChem Substanz-ID: 329823377
• NACRES: NA.24

Eigenschaften

• Qualität: certified reference material; pharmaceutical secondary standard
• Qualitätsniveau: 300
• Agentur: traceable to Ph. Eur. C3250000; traceable to USP 1157002
• API-Familie: cyclophosphamide
• Analysenzertifikat (CofA): current certificate can be downloaded
• Verpackung: pkg of 1 g
• Methode(n): HPLC: suitable; gas chromatography (GC): suitable
• mp (Schmelzpunkt): 49-51 °C (lit.)
• Anwendung(en): pharmaceutical (small molecule)
• Format: neat
• Lagertemp.: 2-8°C
• SMILES String: [H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
• InChI: 1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
• InChIKey: PWOQRKCAHTVFLB-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Cyclophosphamide is one of the cytostatic compounds that is a constituent of several polychemotherapy regimens.

Anwendung

Cyclophosphamide may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations by chromatography techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Biochem./physiol. Wirkung

Cyclophosphamid ist ein Stickstofflostderivat, das in der Krebstherapie verbreitete Anwendung findet. Es führt zur Quervernetzung der DNA sowie zum Abbruch von Strängen und induziert Mutationen. Seine klinische Aktivität wird mit einer Abnahme der ALDH1-Aktivität (Aldehyd-Dehydrogenase 1) assoziiert.

Hinweis zur Analyse

These secondary standards offer multi-traceability to the USP, EP and BP primary standards, where they are available.

Sonstige Hinweise

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Fußnote

To see an example of a Certificate of Analysis for this material enter LRAC0295 in the slot below. This is an example certificate only and may not be the lot that you receive.

Sicherheitshinweise

• Piktogramme: GHS06,GHS08
• Signalwort: Danger
• H-Sätze: H301,H340,H350,H360FD
• P-Sätze: P202 - P264 - P270 - P280 - P301 + P310 - P405
• Gefahreneinstufungen: Acute Tox. 3 Oral - Carc. 1B - Muta. 1B - Repr. 1A
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable