444300

Melatonin

A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals.

• Synonyma: Melatonin, N-Acetyl-5-methoxytryptamine, 5-Methoxy-N-acetyltryptamine
• Empirický vzorec (Hillův zápis): C₁₃H₁₆N₂O₂
• Číslo CAS: 73-31-4
• Molekulová hmotnost: 232.28
• MDL number: MFCD00005655
• UNSPSC Code: 12352200
• NACRES: NA.77

Vlastnosti

• Quality Level: 100
• description: Merck USA index - 14, 5816
• assay: ≥98% (HPLC)
• form: powder
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze; protect from light
• color: white to slightly yellow
• solubility: methanol: 50 mg/mL
• shipped in: ambient
• storage temp.: 2-8°C
• SMILES string: [nH]1c2c(c(c1)CCNC(=O)C)cc(cc2)OC
• InChI: 1S/C13H16N2O2/c1-9(16)14-6-5-10-8-15-13-4-3-11(17-2)7-12(10)13/h3-4,7-8,15H,5-6H2,1-2H3,(H,14,16)
• InChI key: DRLFMBDRBRZALE-UHFFFAOYSA-N

Popis

General description

A hormone that has been postulated as being a mediator of photic-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Inhibits rat cerebellar nitric oxide synthase (NOS).

A hormone that has been postulated as the mediator of photo-induced anti-gonadotropic activity in photoperiodic mammals. Counteracts the apoptotic effects of etoposide in bone marrow cells. Melatonin receptors are coupled to a G-protein system. Exhibits antioxidant properties. Has neuroprotective effects against Aβ peptides. Inhibits rat cerebellar nitric oxide synthase (NOS). Also acts as a peroxynitrite scavenger.

Biochem/physiol Actions

Cell permeable: no

Primary Target
rat NOS

Product does not compete with ATP.

Reversible: no

Warning

Toxicity: Standard Handling (A)

Reconstitution

Following reconstiution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Pappolla, M.A., et al. 2002. J. Pineal Res.32, 135.
Reiter, R.J., and Tan, D.X. 2002. Ann. N.Y. Acad. Sci.957, 341.
Cuzzocrea, S., et al. 1998. J. Pineal Res. 25, 24.
Maestroni, G.J., et al. 1994. Cancer Res. 54, 2429.
Pozo, D., et al. 1994. Life Sciences55, PL455.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Bezpečnostní informace

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 2
• flash_point_f: Not applicable
• flash_point_c: Not applicable