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P-903

Supelco

Protriptyline hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirický vzorec (Hillův zápis):
C19H21N · HCl
Číslo CAS:
1225-55-4
Molekulová hmotnost:
299.84
EC Number:
200-659-6
MDL number:
MFCD00072057
UNSPSC Code:
41116107
PubChem Substance ID:
329820338
NACRES:
NA.24

grade

certified reference material

Quality Level

300

form

liquid

feature

Snap-N-Spike®/Snap-N-Shoot®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol (as free base)

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

2-8°C

SMILES string

CNCCCC1C2=C(C=CC=C2)C=CC3=C1C=CC=C3.[H]Cl

InChI

1S/C19H21N.ClH/c1-20-14-6-11-19-17-9-4-2-7-15(17)12-13-16-8-3-5-10-18(16)19;/h2-5,7-10,12-13,19-20H,6,11,14H2,1H3;1H

InChI key

OGQDIIKRQRZXJH-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A4(6532)

General description

Protriptyline is a second generation tricyclic antidepressant (TCA) marketed under the trade name Vivactil®, for treatment of major depression and ADHD. This certified Snap-N-Spike® solution is applicable for use in LC/MS or GC/MS applications in clinical toxicology, forensic analysis, or urine drug testing. Protriptyline is unique among TCAs, since it has energizing, rather than sedating effects.

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Vivactil is a registered trademark of Teva Women's Health, Inc.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Seznamy omezení vyplývajících z předpisů

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EU REACH Annex XVII (Restriction List)

CAS No.

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Osvědčení o analýze (COA)

Lot/Batch Number

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Y Huang
British journal of pharmacology, 117(3), 533-539 (1996-02-01)
1 The effects of noradrenaline (NA) uptake inhibitors on contractions induced by NA, high K+, and 12-O-tetradecanoylphorbol-13-acetate (TPA) in rat isolated aorta were investigated. 2 Protriptyline (0.3 microM) and amitriptyline (0.3 microM) produced an approximately parallel shift to the right
K E Kinnamon et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 216(3), 424-428 (1997-12-24)
Forty-nine "standard" compounds known to be useful in the treatment of other diseases were tested for their suppressive activity against the trypomastigotes of Trypanosoma cruzi-infected mice. The most active was the antidepressant protriptyline, which was almost three times as effective
T E Wilens et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 35(11), 1485-1490 (1996-11-01)
To evaluate the potential benefit of the tricyclic antidepressant, protriptyline, in the treatment of children and adolescents with attention-deficit hyperactivity disorder (ADHD). All clinic patients in an outpatient pediatric psychopharmacology unit treated with protriptyline for ADHD were monitored for response
J R Wooltorton et al.
British journal of pharmacology, 116(4), 2191-2200 (1995-10-01)
1. The block of K+ currents by amitriptyline and the related tricyclic compounds cyproheptadine and dizocilpine was studied in dissociated rat sympathetic neurones by whole-cell voltage-clamp recording. 2. Cyproheptadine (30 microM) inhibited the delayed-rectifier current (Kv) by 92% and the
B T Duhart et al.
Xenobiotica; the fate of foreign compounds in biological systems, 29(7), 733-746 (1999-08-24)
1. The potential of various fungi to metabolize protriptyline (an extensively used antidepressant) was studied to investigate similarities between mammalian and microbial metabolism. 2. Metabolites produced by each organism were isolated by high-pressure liquid chromatography and identified by nuclear magnetic
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