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A-923

Supelco

Amitriptyline hydrochloride solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Empirický vzorec (Hillův zápis):
C20H24ClN
Číslo CAS:
549-18-8
Molekulová hmotnost:
313.86
EC Number:
200-659-6
UNSPSC Code:
41116107
NACRES:
NA.24

grade

certified reference material

form

liquid

feature

SNAP-N-SPIKE®, SNAP-N-SHOOT®

packaging

ampule of 1 mL

manufacturer/tradename

Cerilliant®

concentration

1.0 mg/mL in methanol

technique(s)

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

application(s)

clinical testing

format

single component solution

storage temp.

−20°C

SMILES string

Cl.CN(C)CC\C=C1\c2ccccc2CCc3ccccc13

InChI

1S/C20H23N.ClH/c1-21(2)15-7-12-20-18-10-5-3-8-16(18)13-14-17-9-4-6-11-19(17)20;/h3-6,8-12H,7,13-15H2,1-2H3;1H

InChI key

KFYRPLNVJVHZGT-UHFFFAOYSA-N

Gene Information

human ... SLC6A2(6530) , SLC6A4(6532)

Související kategorie

General description

A Certified Spiking Solution® suitable for use in LC/MS or GC/MS applications in clinical toxicology, forensic analysis, urine drug testing, prescription monitoring or pharmaceutical research. Amitriptyline, marketed as the brand drug Elavil, Tryptizol, or Laroxyl, is a tricyclic antidepressant used in the treatment of major depression, clinical/endogenous depression and involutional melancholia.

Application


  • Tricyclic antidepressant research: A study demonstrated the use of antisolvent precipitation to formulate excipient-free nanoparticles of psychotropic drugs, including amitriptyline hydrochloride, which could significantly impact the development of novel drug delivery systems for neuropharmacological applications (Wu and Wang, 2022).

  • Neuropharmacology amitriptyline: Research into micellar and interfacial phenomena of amitriptyline hydrochloride with cationic ester-bonded gemini surfactants explored its potential in enhancing drug solubility and stability, which is crucial for neuropharmacological studies and drug delivery systems (Abdul Rub, 2020).

  • Amitriptyline liquid formulation: A methodology to create polymeric nanocarriers containing hydrophilic low molecular-weight drugs, such as amitriptyline, offers a green strategy with very high drug loading, facilitating the development of amitriptyline-based formulations for pharmacological research (Villamizar-Sarmiento et al., 2019).

Legal Information

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
CERTIFIED SPIKING SOLUTION is a registered trademark of Cerilliant Corporation
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

related product

Č. produktu
Popis
Stanovení ceny

A-085

Amitriptyline-d3 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-902

Nortriptyline-D3 hydrochloride solution, 100 μg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

N-907

Nortriptyline hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

P-903

Protriptyline hydrochloride solution, 1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

A-128

Amitriptyline N-ß-D-glucuronide solution, 100 μg/mL in acetonitrile: water (1:1), certified reference material, ampule of 1 mL, Cerilliant®

SMB00969

(E)-10-Hydroxy amitriptyline, ≥95% (HPLC)

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

target_organs

Eyes,Central nervous system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 2

flash_point_f

49.5 °F - closed cup

flash_point_c

9.7 °C - closed cup

Osvědčení o analýze (COA)

Vyhledejte osvědčení Osvědčení o analýze (COA) zadáním čísla šarže/dávky těchto produktů. Čísla šarže a dávky lze nalézt na štítku produktu za slovy „Lot“ nebo „Batch“.

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Navštívit knihovnu dokumentů

[Sweating under polypharmacy with tramadol, amitriptyline and duloxetine?].
Gesine Picksak et al.
Medizinische Monatsschrift fur Pharmazeuten, 36(5), 195-196 (2013-06-14)
David Temesi et al.
Journal of pharmaceutical and biomedical analysis, 76, 164-168 (2013-01-22)
Procedures for drug monitoring based on Dried Blood Spot (DBS) sampling are gaining acceptance for an increasing number of clinical and preclinical applications, where ease of use, small sample requirement, and improved sample stability have been shown to offer advantages
Topical amitriptyline-ketamine for the treatment of brachioradial pruritus.
Timothy J Poterucha et al.
JAMA dermatology, 149(2), 148-150 (2013-02-22)
Daniel J Stein et al.
The Annals of otology, rhinology, and laryngology, 122(1), 20-24 (2013-03-12)
We evaluated the safety and efficacy of amitriptyline hydrochloride in treating idiopathic chronic laryngeal irritability. A retrospective chart review identified patients treated with amitriptyline for laryngeal irritability in an academic otolaryngology practice. Subjects who had documented medication compliance and a
Recreational amitriptyline toxicity mimicking basilar artery stroke.
Jonathan Birns et al.
European journal of emergency medicine : official journal of the European Society for Emergency Medicine, 20(2), 139-140 (2013-02-26)
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