238902

2-(Trimethylsilyl)ethoxymethyl chloride

technical grade

• Synonyma: (2-Chloromethoxyethyl)trimethylsilane, Chloromethyl 2-trimethylsilylethyl ether, SEM-Cl, SEM-chloride
• Lineární vzorec: (CH₃)₃SiCH₂CH₂OCH₂Cl
• Číslo CAS: 76513-69-4
• Molekulová hmotnost: 166.72
• Beilstein/REAXYS Number: 3587289
• EC Number: 278-483-4
• MDL number: MFCD00009919
• UNSPSC Code: 12352101
• PubChem Substance ID: 24854351
• NACRES: NA.22

Vlastnosti

• grade: technical grade
• Quality Level: 100
• form: liquid
• refractive index: n20/D 1.435 (lit.)
• bp: 170-172 °C (lit.); 57-59 °C/8 mmHg (lit.)
• density: 0.942 g/mL at 25 °C (lit.)
• storage temp.: −20°C
• SMILES string: C[Si](C)(C)CCOCCl
• InChI: 1S/C6H15ClOSi/c1-9(2,3)5-4-8-6-7/h4-6H2,1-3H3
• InChI key: BPXKZEMBEZGUAH-UHFFFAOYSA-N

Popis

General description

Learn More at the Professor and Product Portal of Professor Bruce Lipshutz.

Application

Phenol protecting group in the synthesis of laterifluorones.

Used to prepare a SEM-ether which was, in turn, removed with BBr₃ and cyclized to a benzo-oxapane.

Features and Benefits

Convenient hydroxyl-protecting reagent. SEM-ethers are stable over a wide pH range, and can be selectively cleaved with fluoride ion under mild aprotic conditions.

Bezpečnostní informace

• pictograms: GHS02,GHS05
• signalword: Danger
• hcodes: H226,H314
• pcodes: P210 - P233 - P240 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Flam. Liq. 3 - Skin Corr. 1B
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 114.8 °F - closed cup
• flash_point_c: 46 °C - closed cup
• ppe: Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter