MABF850
Anti-IDO-1 Antibody, clone 4B7 | MABF850
clone 4B7, from mouse
Sinónimos:
Indoleamine 2,3-dioxygenase 1, IDO-1, Indoleamine-pyrrole 2,3-dioxygenase
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About This Item
Código UNSPSC:
12352203
eCl@ss:
32160702
NACRES:
NA.41
En este momento no podemos mostrarle ni los precios ni la disponibilidad
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origen biológico
mouse
Nivel de calidad
forma del anticuerpo
purified immunoglobulin
tipo de anticuerpo
primary antibodies
clon
4B7, monoclonal
reactividad de especies
mouse, rat
técnicas
immunohistochemistry: suitable (paraffin)
western blot: suitable
isotipo
IgG1κ
Nº de acceso NCBI
Nº de acceso UniProt
Condiciones de envío
wet ice
modificación del objetivo postraduccional
unmodified
Información sobre el gen
mouse ... Ido1(15930)
Descripción general
Indoleamine 2,3-dioxygenase 1 (EC 1.13.11.52; UniProt P28776; also known as IDO-1, indole 2,3-dioxygenase, Indoleamine-pyrrole 2,3-dioxygenase) is encoded by the Ido1 (also known as Ido, Indo) gene (Gene ID 15930) in murine species. Indoleamine 2,3-dioxygenase-1 (IDO1) is a heme containing enzyme that catalyzes the rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. The reduction in local tryptophan and the upregulated immunomodulatory tryptophan metabolites form the basis of IDO-dependent regulation of inflammation and immunity. IDO is reported to support carcinogenesis by modulating tissue microenvironment inflammatory responses. IDO is also reported to mediate immune escape in cancer by suppressing the function of T effector cells and promote the differentiation of T regulatory cells.
Especificidad
Target specificity of clone 4B7 has been confirmed by both immunohistochemistry and Western blotting using tissue samples from wild-type and Ido1-knockout mice (Thomas, S., et al. (2014). J. Cell. Biochem. 115(2):391-396).
Inmunógeno
KLH-conjugated linear peptide corresponding to the N-terminal region of mouse IDO-1.
Aplicación
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected IDO-1 in rat kidney tissue.
Immunohistochemistry Analysis: A representative lot detected IDO-1 immunoreactivity in acetone-fixed frozen colon tissue sections from wild-type, but not Ido1-knockout mice (Courtesy of Dr. Sunil Thomas, Lankenau Institute for Medical Research, Wynnewood, PA).
Immunofluorescence Analysis: A representative lot detected IDO-1 immunoreactivity in acetone-fixed frozen colon and epididymis tissue sections from wild-type, but not Ido1-knockout mice by fluorescent immunohistochemistry (Courtesy of Dr. Sunil Thomas, Lankenau Institute for Medical Research, Wynnewood, PA).
Western Blotting Analysis: A representative lot detected IDO-1 in epididymis and colon tissue extracts from wild-type, but not Ido1-knockout mice (Thomas, S., et al. (2014). J. Cell. Biochem. 115(2):391-396).
Immunohistochemistry Analysis: A representative lot detected IDO-1 immunoreactivity in multiple acetone-fixed frozen tissue sections from wild-type, but not Ido1-knockout mice, including epididymis, colon, heart, liver, and 4T1-metastasized lung tissue sections (Thomas, S., et al. (2014). J. Cell. Biochem. 115(2):391-396).
Immunohistochemistry Analysis: A representative lot detected IDO-1 immunoreactivity in acetone-fixed frozen colon tissue sections from wild-type, but not Ido1-knockout mice (Courtesy of Dr. Sunil Thomas, Lankenau Institute for Medical Research, Wynnewood, PA).
Immunofluorescence Analysis: A representative lot detected IDO-1 immunoreactivity in acetone-fixed frozen colon and epididymis tissue sections from wild-type, but not Ido1-knockout mice by fluorescent immunohistochemistry (Courtesy of Dr. Sunil Thomas, Lankenau Institute for Medical Research, Wynnewood, PA).
Western Blotting Analysis: A representative lot detected IDO-1 in epididymis and colon tissue extracts from wild-type, but not Ido1-knockout mice (Thomas, S., et al. (2014). J. Cell. Biochem. 115(2):391-396).
Immunohistochemistry Analysis: A representative lot detected IDO-1 immunoreactivity in multiple acetone-fixed frozen tissue sections from wild-type, but not Ido1-knockout mice, including epididymis, colon, heart, liver, and 4T1-metastasized lung tissue sections (Thomas, S., et al. (2014). J. Cell. Biochem. 115(2):391-396).
This Anti-IDO-1 Antibody, clone 4B7 | MABF850 is validated for use in Immunohistochemistry (Paraffin), Western Blotting for the detection of IDO-1.
Calidad
Evaluated by Immunohistochemistry in mouse kidney tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IDO-1 in mouse kidney tissue.
Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected IDO-1 in mouse kidney tissue.
Descripción de destino
~45 kDa calculated
Forma física
Format: Purified
Otras notas
Concentration: Please refer to lot specific datasheet.
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Código de clase de almacenamiento
12 - Non Combustible Liquids
Clase de riesgo para el agua (WGK)
WGK 1
Punto de inflamabilidad (°F)
Not applicable
Punto de inflamabilidad (°C)
Not applicable
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Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Yahya Jand et al.
Scientific reports, 12(1), 15963-15963 (2022-09-25)
Melatonin (MT), a neurohormone with immunomodulatory properties, is one of the metabolites produced in the brain from tryptophan (TRP) that has already strong links with the neuropathogenesis of Multiple sclerosis (MS). However, the exact molecular mechanisms behind that are not
Souvik Dey et al.
Journal for immunotherapy of cancer, 8(2) (2020-07-22)
The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpreted as counterbalancing IDO1-mediated immunosuppression. Based on this hypothesis, clinical studies
Yuying Liu et al.
Nature communications, 8, 15207-15207 (2017-05-11)
Interactions with the immune system may lead tumorigenic cells into dormancy. However, the underlying molecular mechanism is poorly understood. Using a 3D fibrin gel model, we show that IFN-γ induces tumour-repopulating cells (TRCs) to enter dormancy through an indolamine 2,3-dioxygenase
Tatsuya Ando et al.
Molecular medicine reports, 27(2) (2022-12-10)
The partial loss of liver due to liver transplantation or acute liver failure induces rapid liver regeneration. Recently, we reported that the selective inhibition of indoleamine 2,3‑dioxygenase (Ido) 1 promotes early liver regeneration. However, the role of Ido2 in liver
Willy Jaya Suento et al.
Journal of neurochemistry, 157(6), 1963-1978 (2020-10-24)
Indoleamine 2,3-dioxygenase 1 (IDO1) is the first rate-limiting enzyme that metabolizes tryptophan to the kynurenine pathway. Its activity is highly inducible by pro-inflammatory cytokines and correlates with the severity of major depressive disorder (MDD). MicroRNAs (miRNAs) are involved in gene
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