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Merck
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Documenti

J4455

Sigma-Aldrich

JSH-23

≥98% (HPLC), solid

Sinonimo/i:

4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine

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About This Item

Formula empirica (notazione di Hill):
C16H20N2
Numero CAS:
749886-87-1
Peso molecolare:
240.34
Codice UNSPSC:
51111800
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

protect from light

Colore

off-white to gray-pink

Solubilità

DMSO: >10 mg/mL

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

InChI

1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
YMFNPBSZFWXMAD-UHFFFAOYSA-N

Applicazioni

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.

Azioni biochim/fisiol

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Altre note

Light and air sensitive.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

S1697

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Sigma-Aldrich

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NF-κB Activation Inhibitor

IMD-0354 ≥98% (HPLC), solid

Sigma-Aldrich

I3159

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TPCA-1 ≥95% (HPLC)

Sigma-Aldrich

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SN50 trifluoroacetate salt ≥95% (HPLC)

Sigma-Aldrich

SML1471

SN50 trifluoroacetate salt

Sodium 4-aminosalicylate dihydrate ≥97.0% (T)

Sigma-Aldrich

09415

Sodium 4-aminosalicylate dihydrate

TLR4 Inhibitor, TAK-242 TAK-242; CAS 243984-11-4; is a cell-permeable compound that selectively binds to Cys747 of TLR4 and selectively disrupts its interaction with adaptor molecules TIRAP and TRAM.

Sigma-Aldrich

614316

TLR4 Inhibitor, TAK-242

Ammonium pyrrolidinedithiocarbamate ~99%

Sigma-Aldrich

P8765

Ammonium pyrrolidinedithiocarbamate

Rolipram solid, ≥98% (HPLC)

Sigma-Aldrich

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Rolipram

HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-?B pathway in acute glaucoma.
Chi W et al.
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L Shi et al.
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The coordination between cellular differentiation and the mesenchymal/stem transition is essential for both embryo development and neoplasia, suggesting a mechanistic link between these two major processes. In this work we show that miR-127, an embryo-expressing lung miRNA, was prominently induced
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Transcription factor 4 (TCF-4) was recently identified as a candidate gene for the cause of type 2 diabetes, although the mechanisms have not been fully elucidated. In the present study, we demonstrated that the TCF-4 transgene in macrophages aggravated high-fat diet
Macrophage TCF-4 co-activates p65 to potentiate chronic inflammation and insulin resistance in mice.
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Papillary thyroid carcinomas (PTCs) have an excellent prognosis, but a fraction of them show aggressive behavior, becoming radioiodine (RAI)-resistant and/or metastatic. AXL (Anexelekto) is a tyrosine kinase receptor regulating viability, invasiveness and chemoresistance in various human cancers, including PTCs. Here
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