481408-M

NF-κB Activation Inhibitor II, JSH-23

The NF-κB Activation Inhibitor II, JSH-23, also referenced under CAS 749886-87-1, controls the biological activity of NF-κB. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

• Sinonimo/i: NF-κB Activation Inhibitor II, JSH-23, 4-Methyl-N¹-(3-phenylpropyl)benzene-1,2-diamine
• Formula empirica (notazione di Hill): C₁₆H₂₀N₂
• Numero CAS: 749886-87-1
• Peso molecolare: 240.34
• Numero MDL: MFCD09753595
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥95% (HPLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze; protect from light
• Colore: off-white
• Solubilità: DMSO: 10 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: N(CCCc2ccccc2)c1c(cc(cc1)C)N
• InChI: 1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3; YMFNPBSZFWXMAD-UHFFFAOYSA-N

Descrizione

Descrizione generale

A cell-permeable diamino compound that selectively blocks nuclear translocation of NF-κB p65 and its transcription activity (IC₅₀ = 7.1 µM in a NF-κB reporter assay using RAW 264.7) without affecting IκB degradation. Shown to suppress DNA-binding of NF-κB and downregulate LPS-induced gene expression and apoptotic chromatin condensation.

A cell-permeable, selective blocker of the nuclear translocation of NF-κB p65 that does not affect IκB degradation (IC₅₀ = 7.1 µM in LPS-stimulated macrophages RAW 264.7 stably transfected with pNF-κB-SEAP-NPT). Shown to suppress DNA-binding of NF-κB and downregulate LPS-inducible expression of TNF-α, IL-1β, IL-6, iNOS, and COX-2. Also prevents LPS-induced apoptotic chromatin condensation.

Azioni biochim/fisiol

Primary Target
Blocks nuclear translocation of NF-κB p65 and its transcription activity

Target IC₅₀: 7.1 µM in a NF-κB reporter assay using RAW 264.7

Attenzione

Toxicity: Standard Handling (A)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Shin, H.M., et al. 2004. FEBS Lett.571, 50.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3