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T1452

Sigma-Aldrich

TPCA-1

≥95% (HPLC)

Sinonimo/i:

[5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide

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About This Item

Formula empirica (notazione di Hill):
C12H10FN3O2S
Numero CAS:
507475-17-4
Peso molecolare:
279.29
Numero MDL:
MFCD09037541
Codice UNSPSC:
12352200
ID PubChem:
329826675
NACRES:
NA.77

Saggio

≥95% (HPLC)

Forma fisica

powder

Colore

white to light brown

Solubilità

DMSO: 5 mg/mL, clear

Ideatore

GlaxoSmithKline

Temperatura di conservazione

2-8°C

Stringa SMILE

NC(=O)Nc1sc(cc1C(N)=O)-c2ccc(F)cc2

InChI

1S/C12H10FN3O2S/c13-7-3-1-6(2-4-7)9-5-8(10(14)17)11(19-9)16-12(15)18/h1-5H,(H2,14,17)(H3,15,16,18)
SAYGKHKXGCPTLX-UHFFFAOYSA-N

Applicazioni

TPCA-1 has been used to study its cytotoxic effects in RPMI8226 and LP1 cell lines. It has also been used as a culture media supplement for nuclear protein fractions extracted from human airway smooth muscle cells.

Azioni biochim/fisiol

TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1. It has been used to study inhibition of IKK-2 to prevent inflammatory mediator release in animal models of arthritis and airway inflammation.

Caratteristiche e vantaggi

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Nota sulla preparazione

TPCA-1 is soluble in DMSO at a concentration that is greater than or equal to 10 mg/ml. It is insoluble in water.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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