C2932

Chelerythrine chloride

≥95% (TLC), powder

• Sinonimo/i: 1,2-Dimethoxy-N-methyl(1,3)benzodioxolo(5,6-c)phenanthridinium chloride, Toddaline chloride
• Formula empirica (notazione di Hill): C₂₁H₁₈ClNO₄
• Numero CAS: 3895-92-9
• Peso molecolare: 383.82
• Numero MDL: MFCD00060717
• Codice UNSPSC: 12352200
• ID PubChem: 24278305
• NACRES: NA.77

Proprietà

• Origine biologica: plant
• Saggio: ≥95% (TLC)
• Stato: powder
• Colore: yellow to orange
• Punto di fusione: 213.0-214.0 °C
• Solubilità: DMSO: 2 mg/mL
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl.COc1ccc2-c3ccc4cc5OCOc5cc4c3[N](C)=Cc2c1OC
• InChI: 1S/C21H18NO4.ClH/c1-22-10-16-13(6-7-17(23-2)21(16)24-3)14-5-4-12-8-18-19(26-11-25-18)9-15(12)20(14)22;/h4-10H,11H2,1-3H3;1H; SUPBMPBJXZDANZ-UHFFFAOYSA-N

Descrizione

Descrizione generale

Chelerythrine chloride (CHE), a benzophenanthridine alkaloid[1] is an inhibitor of protein kinase C (PKC).[2] It is the active component of Macleaya cordata.[3]

Applicazioni

Chelerythrine chloride has been used:

• as a supplement in heat-inactivated late-embryo extract or late-embryo extract to inhibit protein kinase C (PKC) activity[4]
• for in vitro Xenopus experiments[4]
• as a PKC inhibitor in HL-1 cells[5], to block the PKC pathway to study its effects on doxazosin-induced galectin-3 and collagen expression[6]

Azioni biochim/fisiol

Chelerythrine chloride (CHE) is capable of preventing the growth and apoptosis in human gastric cancer BGC-823 cells.[3] It possesses several biological effects and also can induce the phosphorylation of a ~20 kDa protein present in the mitochondrial fraction of the rat retina.[1]

Caratteristiche e vantaggi

This compound is featured on the P2 Receptors: P2X Ion Channel Family and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302 + H312 + H332,H315,H319,H335
• Consigli di prudenza: P261 - P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable