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G1918

Sigma-Aldrich

Gö 6983

≥97%

Sinonimo/i:

3-[1-[3-(Dimethylamino)propyl]-5-methoxy-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione

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About This Item

Formula empirica (notazione di Hill):
C26H26N4O3
Numero CAS:
133053-19-7
Peso molecolare:
442.51
Numero MDL:
MFCD04040031
Codice UNSPSC:
12352200
ID PubChem:
24894916
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥97%

Stato

powder

Solubilità

DMSO: 10 mg/mL, clear

Temperatura di conservazione

−20°C

Stringa SMILE

COc1ccc2n(CCCN(C)C)cc(C3=C(C(=O)NC3=O)c4c[nH]c5ccccc45)c2c1

InChI

1S/C26H26N4O3/c1-29(2)11-6-12-30-15-20(18-13-16(33-3)9-10-22(18)30)24-23(25(31)28-26(24)32)19-14-27-21-8-5-4-7-17(19)21/h4-5,7-10,13-15,27H,6,11-12H2,1-3H3,(H,28,31,32)
LLJJDLHGZUOMQP-UHFFFAOYSA-N

Applicazioni

GO6983 has been used as a protein kinase C (PKC) inhibitor to study its effects on the nuclear import. It has also been used as a supplement in Fc medium to culture mouse embryonic stem (mES) cells on mitomycin C treated mouse embryonic fibroblasts (MEFs).

Azioni biochim/fisiol

Protein kinase C (PKC) inhibitor that selectively inhibits several PKC isozymes (IC50 = 7 nM for PKCα and PKCβ; 6 nM for PKCγ; 10 nM for PKCδ; and 60 nM for PKCζ), but does not inhibit PKCμ (IC50 = 20 mM).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
0000216275
0000216268
0000183858
066M4627V

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Bisindolylmaleimide II ≥97% (Mixture of 2 isomers)

Sigma-Aldrich

B3056

Bisindolylmaleimide II

Bisindolylmaleimide I A highly selective, cell-permeable, and reversible protein kinase C (PKC) inhibitor (IC₅₀ = 10 nM) that is structurally similar to staurosporine.

Sigma-Aldrich

203290

Bisindolylmaleimide I

Bisindolylmaleimide X hydrochloride ≥90%, solid

Sigma-Aldrich

B3931

Bisindolylmaleimide X hydrochloride

Pluripotent state transitions coordinate morphogenesis in mouse and human embryos
Shahbazi MN, et al.
Nature, 552(7684), 239-239 (2017)
Ohad Gafni et al.
Nature, 504(7479), 282-286 (2013-11-01)
Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2
Shirley E Bradley et al.
The Journal of biological chemistry, 285(7), 4883-4895 (2009-11-18)
Expression of the VACM-1/cul5 gene in endothelial and in cancer cell lines in vitro inhibits cellular proliferation and decreases phosphorylation of MAPK. Structure-function analysis of the VACM-1 protein sequence identified consensus sites specific for phosphorylation by protein kinases A and
Debasree Dutta et al.
Stem cells (Dayton, Ohio), 29(4), 618-628 (2011-02-11)
The intricate molecular mechanisms that regulate ESC pluripotency are incompletely understood. Prior research indicated that activation of the Janus kinase-signal transducer and activator of transcription (STAT3) pathway or inhibition of extracellular signal-regulated kinase/glycogen synthase kinase 3 (ERK/GSK3) signaling maintains mouse
Li-Chun Lisa Tsai et al.
The Journal of biological chemistry, 290(36), 21845-21856 (2015-07-19)
Atypical protein kinase C (aPKC) enzymes signal on protein scaffolds, yet how they are maintained in an active conformation on scaffolds is unclear. A myristoylated peptide based on the autoinhibitory pseudosubstrate fragment of the atypical PKCζ, zeta inhibitory peptide (ZIP)
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