T6031

DL-Thiorphan

≥98% (TLC)

• Synonym(e): (±)-N-(3-Mercapto-2-benzylpropionyl)-glycin
• Empirische Formel (Hill-System): C₁₂H₁₅NO₃S
• CAS-Nummer: 76721-89-6
• Molekulargewicht: 253.32
• Beilstein: 4872101
• MDL-Nummer: MFCD00058435
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24278747
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥98% (TLC)
• Form: powder
• mp (Schmelzpunkt): 138 °C
• Löslichkeit: ethanol: soluble 49.00-51.00 mg/mL, clear, colorless
• SMILES String: OC(=O)CNC(=O)C(CS)Cc1ccccc1
• InChI: 1S/C12H15NO3S/c14-11(15)7-13-12(16)10(8-17)6-9-4-2-1-3-5-9/h1-5,10,17H,6-8H2,(H,13,16)(H,14,15)
• InChIKey: LJJKNPQAGWVLDQ-UHFFFAOYSA-N
• Angaben zum Gen: human ... ACE(1636) , ECE1(1889) ; rat ... Ace(24310) , Mme(24590)

Beschreibung

Allgemeine Beschreibung

Thiorphan, also called DL-mercapto-2-benzylpropanoyl-glycine is a specific and potent inhibitor of enkephalinase in nanomolar concentrations.[1] It is an inhibitor of neutral endopeptidase. It interacts with cluster of differentiation 10 (CD10) in bone marrow cells and may modulate hematopoiesis.[2] Thiorphan is a safe drugprescribed for diarrhea. It prevents cortical damage in newborn mice and is a potent agent for treating cerebral palsy.(CP)[3]

Anwendung

DL-Thiorphan has been used to evaluate the activity of NEP-dependent neutral endopeptidase.[4] DL-Thiorphan has also been used for determining NEP enzymatic activity using fluorimetric assays.[5]

Biochem./physiol. Wirkung

Enkephalinase-Inhibitor

Leistungsmerkmale und Vorteile

This compound is featured on the Neuropeptidases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Angaben zur Herstellung

DL-Thiorphan is soluble in ethanol at 49.00 - 51.00 mg/ml and yields a clear, colorless solution.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)