Direkt zum Inhalt
Merck
Alle Fotos(1)

Dokumente

SRP6505

Sigma-Aldrich

G6PD human

recombinant, expressed in E. coli, ≥95% (SDS-PAGE)

Synonym(e):

Glucose-6-phosphate 1-dehydrogenase, Zwf

Anmeldenzur Ansicht organisationsspezifischer und vertraglich vereinbarter Preise
Alle Fotos(1)

About This Item

UNSPSC-Code:
12352204
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥95% (SDS-PAGE)

Form

liquid

Mol-Gew.

61.4 kDa (515 aa, 1- 515 aa)

Verpackung

pkg of 100 μg

Konzentration

0.5 mg/mL

UniProt-Hinterlegungsnummer

P11413

Versandbedingung

wet ice

Lagertemp.

−20°C

Angaben zum Gen

human ... G6PD(2539)

Allgemeine Beschreibung

G6PD (glucose-6-phosphate dehydrogenase) gene is mapped to human chromosome Xq28, and spans 16.2kb. One G6PD monomer is composed of 515 amino acids with a predicted molecular weight of 59,256Da. The active enzyme exists as a dimer, and contains an NADP molecule tightly bound to it.

Biochem./physiol. Wirkung

G6PD (glucose-6-phosphate dehydrogenase) enzyme catalyzes the oxidation of glucose-6-phosphate to 6-phosphogluconolactone, reducing NADP to NADPH. It therefore, catalyzes the first step of hexose monophosphate pathway (HMP). As it is responsible for the oxidation of glucose-6-phosphate, and thus, confers protection against oxidative damage in erythrocytes. Its deficiency is highly heterogenous, with around 190 variants being reported. The deficiency of G6PD was discovered while studying hemolytic anemia. G6PD also results in hereditary nonspherocytic hemolytic anemia.

Physikalische Form

0.5 mg/mL solution in 20 mM Tris-HCl buffer (pH 8.0) containing 20% glycerol, 0.1 mM PMSF, 2 mM EDTA, 2 mM DTT, 200 mM NaCl.

Hinweis zur Analyse

The biological activity is > 7 units/ml obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NAD or NADP. One unit oxidizes 1.0 μmole D-glucose-6-phosphate to 6-phospho-Dgluconate per min in the presence of beta-NADP at pH 7.4 at 25 °C.

Piktogramme

Exclamation mark
GHS07

Signalwort

Warning

H-Sätze

H315,H319

Gefahreneinstufungen

Eye Irrit. 2 - Skin Irrit. 2

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

Besitzen Sie dieses Produkt bereits?

In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

Kunden haben sich ebenfalls angesehen

Slide 1 of 4

1 of 4

Glucose-6-phosphat mol wt (glucose-6-P: Mr = 260.2, glucose-6-P-Na2: Mr = 304.2), pkg of 5 g

Roche

10127647001

Glucose-6-phosphat

Bilirubin ≥98% (EmM/453 = 60), powder

Sigma-Aldrich

B4126

Bilirubin

NADP Disodium salt

Roche

NADP-RO

NADP

Hämoglobin human lyophilized powder

Sigma-Aldrich

H7379

Hämoglobin human

Glucose-6-phosphate dehydrogenase deficiency: a historical perspective.
Beutler E
Blood, 111(1), 16-24 (2008)
African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania.
Manjurano A, et al.
PLoS Genetics, 11(2) (2015)
G6PD deficiency.
E Beutler
Blood, 84(11), 3613-3636 (1994-12-01)
Saúl Gómez-Manzo et al.
International journal of molecular sciences, 15(11), 21179-21201 (2014-11-20)
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency worldwide, causing a wide spectrum of conditions with severity classified from the mildest (Class IV) to the most severe (Class I). To correlate mutation sites in the G6PD with the
Francesco Ciscato et al.
Bio-protocol, 11(14), e4087-e4087 (2021-08-17)
The crucial role of hexokinase 2 (HK2) in the metabolic rewiring of tumors is now well established, which makes it a suitable target for the design of novel therapies. However, hexokinase activity is central to glucose utilization in all tissues;
Alle zugehörigen Dokumente anzeigen

Unser Team von Wissenschaftlern verfügt über Erfahrung in allen Forschungsbereichen einschließlich Life Science, Materialwissenschaften, chemischer Synthese, Chromatographie, Analytik und vielen mehr..

Setzen Sie sich mit dem technischen Dienst in Verbindung.